A patient is receiving warfarin (Coumadin), which is 98% bound to plasma proteins. The antidepressant paroxetine (Paxil), which is 95% bound to plasma proteins, is added to the patient's daily medication. If the paroxetine displaces warfarin from its protein binding sites, which of the following will most likely to occur?
Diminished effect from warfarin
Diminished effect from paroxetine
Increased effect, and toxicity from paroxetine
Increased effect, and toxicity from warfarin
The Correct Answer is D
A. Diminished effect from warfarin: This is unlikely because displacement of warfarin from protein binding sites would increase its concentration in the bloodstream, potentially leading to increased anticoagulant effects and toxicity.
B. Diminished effect from paroxetine: This is also unlikely because displacement of paroxetine from protein binding sites would increase its concentration in the bloodstream, potentially leading to increased pharmacological effects and toxicity.
C. Increased effect, and toxicity from paroxetine: If paroxetine displaces warfarin from protein binding sites, it can increase the concentration of free warfarin in the bloodstream, leading to increased anticoagulant effects and potential toxicity.
D. Increased effect, and toxicity from warfarin: Correct. If warfarin is displaced from protein binding sites by paroxetine, it can increase the concentration of free warfarin in the bloodstream, leading to increased anticoagulant effects and potential toxicity.
Nursing Test Bank
Naxlex Comprehensive Predictor Exams
Related Questions
Correct Answer is C
Explanation
A. Ferrous sulfate: This is an iron supplement and wouldn't be used to reverse warfarin's anticoagulant effect.
B. Prednisone: This is a steroid medication used for various inflammatory conditions and wouldn't be used to address excessive blood thinning.
C. Vitamin K: Vitamin K is the antidote for warfarin poisoning or excessive anticoagulation. By providing vitamin K, the body can resume producing clotting factors, counteracting warfarin's effect.
D. Heparin: This is another blood thinner medication. While it can be used in specific situations, it wouldn't be the first choice to reverse warfarin's effect because it adds another layer of anticoagulation, which could be risky.
Correct Answer is D
Explanation
A. Trombin (Evithrom): Incorrect: Thrombin (also known as factor IIa) is not typically used as a hemostatic drug. It is involved in the final step of the coagulation cascade, converting fibrinogen to fibrin to form a stable clot. However, it is not administered directly as a medication.
B. Aminocaproic acid (Amicar): Aminocaproic acid is an antifibrinolytic agent commonly used to control bleeding. It works by inhibiting the breakdown of fibrin clots, thus promoting hemostasis. It is particularly useful in situations where excessive bleeding occurs due to impaired clot dissolution. However, tranexamic acid is generally considered more potent and has a longer-lasting effect, making it the preferred choice in many situations.
C. Aspirin: Incorrect: Aspirin is an antiplatelet medication that inhibits platelet aggregation. While it can reduce the risk of clot formation, it is not primarily used for controlling postoperative bleeding.
D. Tranexamic acid (Cyklokapron): Correct: Tranexamic acid is another antifibrinolytic agent that helps prevent excessive bleeding. It works by blocking the breakdown of fibrin clots. Tranexamic acid is commonly used in surgical settings to manage bleeding during and after procedures.
Whether you are a student looking to ace your exams or a practicing nurse seeking to enhance your expertise , our nursing education contents will empower you with the confidence and competence to make a difference in the lives of patients and become a respected leader in the healthcare field.
Visit Naxlex, invest in your future and unlock endless possibilities with our unparalleled nursing education contents today
Report Wrong Answer on the Current Question
Do you disagree with the answer? If yes, what is your expected answer? Explain.
Kindly be descriptive with the issue you are facing.