Disruption of which neurotransmitter is involved in Parkinson's disease?
Acetylcholine.
Dopamine.
Serotonin.
Norepinephrine.
The Correct Answer is B
Choice A rationale
Acetylcholine is an excitatory neurotransmitter in the basal ganglia. In Parkinson's disease, there is a relative overactivity of acetylcholine because there is not enough dopamine to inhibit it. While the imbalance between acetylcholine and dopamine is crucial to the disease's symptoms, the primary disruption and the root cause of the pathology is the loss of dopamine. Anticholinergic medications are sometimes used to restore balance, but they do not address the primary neurochemical deficit.
Choice B rationale
Parkinson's disease is directly caused by the progressive degeneration of dopaminergic neurons in the substantia nigra pars compacta. Dopamine is essential for the smooth, coordinated regulation of muscle movement via the basal ganglia. When dopamine levels fall by approximately 60 to 80 percent, the classic motor symptoms emerge. Most pharmacological treatments, such as Levodopa, aim to increase dopamine levels or mimic its action at the receptor site to alleviate bradykinesia, tremors, and muscle rigidity.
Choice C rationale
Serotonin is involved in mood, sleep, and appetite regulation. While patients with Parkinson's disease often suffer from depression and sleep disturbances due to secondary changes in serotonergic pathways, serotonin is not the primary neurotransmitter responsible for the motor dysfunction that defines the disease. The loss of serotonin-producing neurons may occur as the disease spreads to other brain regions, but it is considered a non-motor complication rather than the central cause of the disorder's hallmark signs.
Choice D rationale
Norepinephrine is produced by neurons that are also affected in Parkinson's disease, particularly in the locus coeruleus. This loss contributes to non-motor symptoms like orthostatic hypotension and fatigue. However, the cardinal motor features like bradykinesia and rigidity are specifically linked to the dopamine deficit. While norepinephrine plays a role in the overall clinical picture of autonomic dysfunction in Parkinson's, it is not the primary neurotransmitter whose disruption characterizes the core movement disorder.
Nursing Test Bank
Naxlex Comprehensive Predictor Exams
Related Questions
Correct Answer is A
Explanation
Choice A rationale
Hepatitis B is a DNA virus that is highly contagious through parenteral routes. It is found in the highest concentrations in blood, with lower concentrations in semen and vaginal secretions. Transmission occurs when these fluids enter the body of a non-immune person through breaks in the skin or mucous membranes. This can happen through sexual intercourse, sharing needles, or from an infected mother to her infant during childbirth. It is not spread through air.
Choice B rationale
Respiratory droplets are the primary mode of transmission for viruses like influenza or SARS-CoV-2, which infect the respiratory tract. Hepatitis B is not a respiratory virus; it does not replicate in the lungs or shed through coughing and sneezing. Therefore, being in the same room as an infected person or breathing the same air does not pose a risk for contracting the virus. Transmission requires more direct contact with specific internal body fluids.
Choice C rationale
Contaminated food and water are vehicles for enterically transmitted viruses like Hepatitis A and E. These viruses are shed in the feces and enter the new host through the mouth. Hepatitis B, however, is not shed in feces in significant amounts and is not hardy enough to survive the digestive processes or environmental conditions typical of foodborne transmission. Consequently, eating food prepared by someone with Hepatitis B is not considered a significant risk.
Choice D rationale
Casual contact, such as hugging, shaking hands, or sharing utensils, does not transmit Hepatitis B. The virus cannot penetrate intact skin and is not found in sweat or tears in levels sufficient for transmission. Education regarding this is vital to reduce the stigma associated with the diagnosis. Patients do not need to be isolated from family members in a household setting, provided they do not share personal items like razors or toothbrushes.
Correct Answer is B
Explanation
Choice A rationale
This term describes the presence of excess fat in the feces, which often results in stools that are bulky, foul-smelling, and oily. This condition is typically caused by malabsorption syndromes, such as celiac disease or cystic fibrosis, where the body cannot properly digest or absorb dietary fats. It has no physiological connection to the vomiting of blood and involves the lower digestive outcomes rather than an acute upper gastrointestinal emergency or vascular rupture.
Choice B rationale
This is the correct medical term for the vomiting of blood, which can appear as bright red or like coffee grounds depending on how long it has been in contact with gastric acid. Bright red blood indicates an active, brisk bleed in the upper gastrointestinal tract, such as from esophageal varices or a gastric ulcer. It is a critical clinical finding that requires immediate assessment of hemodynamic stability, as the patient is losing active blood volume.
Choice C rationale
This is a general term for inflammation of the stomach and intestines, commonly caused by viral or bacterial infections. While it can cause significant vomiting and diarrhea, the emesis is usually composed of food or bile rather than bright red blood. While severe irritation can occasionally lead to streaks of blood, the term itself refers to the inflammatory state of the gut lining and does not specifically define the clinical act of vomiting blood.
Choice D rationale
This term refers to the passage of black, tarry stools that result from the digestion of blood in the gastrointestinal tract. While it indicates a bleed, it describes the appearance of blood that has passed through the intestines and been oxidized by acid and bacteria. It is the result of upper gastrointestinal bleeding but is a finding associated with defecation, not the act of vomiting, making it the incorrect term for this specific patient complaint.
Whether you are a student looking to ace your exams or a practicing nurse seeking to enhance your expertise , our nursing education contents will empower you with the confidence and competence to make a difference in the lives of patients and become a respected leader in the healthcare field.
Visit Naxlex, invest in your future and unlock endless possibilities with our unparalleled nursing education contents today
Report Wrong Answer on the Current Question
Do you disagree with the answer? If yes, what is your expected answer? Explain.
Kindly be descriptive with the issue you are facing.
