The topical product shown below contains how many mg of the active ingredient Crisaborole in each gram of the product?
[Image of Eucrisa (crisaborole) ointment 2%]
200 mg.
2 mg.
20 g.
20 mg.
2 g.
The Correct Answer is D
Step 1. Define the 2% concentration.
2% w/w means 2 g of drug in 100 g of ointment.
Step 2. Convert to mg per 100 g.
2 g x 1,000 mg/g = 2,000 mg per 100 g.
Step 3. Calculate mg per 1 gram.
2,000 mg / 100 g =
20 mg per 1 gram.
Nursing Test Bank
Naxlex Comprehensive Predictor Exams
Related Questions
Correct Answer is A
Explanation
Lactulose is a synthetic disaccharide consisting of galactose and fructose that remains unabsorbed in the small intestine. It functions as an osmotic agent, drawing water into the colonic lumen to soften stool and stimulate peristalsis. Additionally, it is used to manage hepatic encephalopathy by acidifying the gut and converting ammonia to unabsorbable ammonium ions. It is a vital medication for both gastrointestinal and hepatic disorders.
Rationale:
A. Laxative is the correct therapeutic class. Specifically, lactulose is an osmotic laxative. By increasing the osmotic pressure in the colon, it promotes fluid retention and increases bowel motility. It is commonly used for chronic constipation and is particularly effective when a soft stool is required to prevent straining during defecation in high-risk cardiac or surgical patients.
B. Antidepressants are medications used to treat mood disorders by modulating neurotransmitters like serotonin and norepinephrine. Lactulose has no pharmacological activity in the central nervous system related to mood regulation. It does not cross the blood-brain barrier in significant amounts and lacks affinity for monoamine transporters. Therefore, it has no utility in treating clinical depression.
C. Antipsychotics are used to manage symptoms of schizophrenia and bipolar disorder by blocking dopamine receptors. Lactulose is a sugar derivative that stays within the gastrointestinal tract and does not interact with dopaminergic pathways. Its therapeutic effects are restricted to osmotic and acid-base changes in the bowel, rendering it useless for the management of psychosis or hallucinations.
D. Antidiabetics are agents that lower blood glucose levels, such as metformin or insulin. Despite being a disaccharide, lactulose is not absorbed and therefore does not raise or lower serum glucose significantly. It is not used to treat hyperglycemia; in fact, diabetic patients must use it with caution as small amounts of free sugars may be present in the solution.
Correct Answer is ["1310.4"]
Explanation
Step 1 is to convert the weight from pounds (lbs) to kilograms (kg)
Weight in kg = 154 ÷ 2.2
154 ÷ 2.2 = 70
Result at this step = 70 kg
Step 2 is to calculate the total volume (mL) to be administered
Volume = Weight in kg × Dose (mL/kg)
70 × 0.06 = 4.2
Result at this step = 4.2 mL
Step 3 is to calculate the dose in units
Total Units = Total mL × Concentration (IU/mL)
4.2 × 312 = 1310.4
Result at this step = 1310.4
Step 4 is to round to the nearest tenth
1310.4 = 1310.4
Answer: 1310.4
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