Tygacil 50 milligrams IV once a day is ordered for a patient.

The Tygacil is dissolved in 50 milliliters of Normal Saline and should infuse over 30 minutes.

Using an IV pump, how many milliliters per hour will you administer the medication? Whole number.

Step 1 is to convert the ordered dose from grams to milligrams to match the available concentration. 0.5 grams × (1000 milligrams ÷ 1 gram) = 500 milligrams.

Step 2 is to calculate the volume to administer using the available concentration. 500 milligrams ÷ (330 milligrams ÷ 1 milliliter) = 1.51515. milliliters.

Step 3 is to round the calculated volume to the tenths place as required. The nurse will administer 1.5 milliliters.

Choice A rationale

Administering 6 L of oxygen is an important intervention in sickle cell crisis to address tissue hypoxia. However, a severe headache in a child with vaso-occlusive crisis may signal a more critical complication like a cerebrovascular accident (stroke), which necessitates immediate neurological assessment before other routine interventions.

Choice B rationale

A severe headache in a child experiencing a sickle cell vaso-occlusive crisis is a red flag for central nervous system complications, most critically a stroke, which requires immediate and detailed neurological assessment. Establishing the baseline status is the priority to rapidly detect changes and initiate emergency stroke protocol and treatment.

Choice C rationale

Administering a narcotic analgesic is crucial for pain management in a vaso-occlusive crisis. However, giving an opioid before assessing neurological status could potentially mask or alter signs of a life-threatening stroke or increased intracranial pressure, delaying critical interventions for a neurological emergency.

Choice D rationale

Increasing the IV rate is an appropriate intervention to promote hydration and hemodilution, which can help reverse the sickling process. While important, addressing the severe headache requires first ruling out or confirming a serious neurological event through a focused assessment, making assessment the immediate priority.