Which of the following transdermal products is used once weekly?
Daytrana.
Catapres-TTS-3.
NicoDerm.
Nitro-Dur.
Vivelle-Dot.
The Correct Answer is B
Transdermal therapeutic systems (TTS) are designed to deliver a steady state of medication across the skin into the systemic circulation. These patches use either a reservoir or matrix design to control the rate of drug release over a specific duration. The wear time is determined by the drug's half-life and the patch's diffusion capacity. Proper patient education regarding the frequency of patch changes is critical to avoid sub-therapeutic levels or drug accumulation.
Rationale:
A. Daytrana is a methylphenidate patch used for ADHD and is applied daily. It is specifically designed to be worn for only 9 hours and then removed to avoid insomnia and mimic the pharmacokinetic profile of oral stimulants. It does not have the drug reservoir capacity to maintain therapeutic levels for an entire week. Daily application is required for symptom management.
B. Catapres-TTS-3 contains clonidine and is specifically engineered for once-weekly application. The patch utilizes a programmed delivery system that maintains a constant plasma concentration of the antihypertensive agent for 7 days. This long duration improves patient adherence by reducing the frequency of dosing. It is one of the most common examples of a long-acting transdermal system.
C. NicoDerm CQ is a nicotine replacement patch used for smoking cessation that must be replaced every 24 hours. Continuous nicotine delivery is required to manage withdrawal symptoms, but the patch does not contain enough active ingredient to last beyond one day. A fresh patch is needed daily to maintain consistent serum nicotine levels. Using it weekly would lead to treatment failure.
D. Nitro-Dur contains nitroglycerin and is typically worn for only 12 to 14 hours a day. It requires a "patch-free" interval of 10 to 12 hours to prevent the development of nitrate tolerance. Because the body quickly desensitizes to continuous nitroglycerin, a weekly patch would be clinically ineffective. Daily application and removal are the standard therapeutic protocol.
E. Vivelle-Dot is an estradiol patch used for hormone replacement therapy and is applied twice weekly. The patch is changed every 3 to 4 days (e.g., on Monday and Thursday) to maintain stable estrogen levels. While it lasts longer than a daily patch, it does not reach the seven-day duration of a clonidine patch. It is a multi-day but not weekly system.
Nursing Test Bank
Naxlex Comprehensive Predictor Exams
Related Questions
Correct Answer is C
Explanation
Szasz and Hollender developed a framework to describe the dynamics of the patient-provider relationship based on the patient's level of function. These models describe how clinical authority is distributed during the therapeutic encounter. The choice of model often depends on the severity of the medical condition and the patient's ability to contribute to their own care. Understanding these models helps practitioners adapt their communication style to improve outcomes.
Rationale:
A. Activity-passivity is a model where the practitioner is entirely in control and the patient is a passive recipient of care. This occurs in emergency situations, such as when a patient is unconscious or in a coma. There is no opportunity for partnership because the patient cannot communicate. It represents the most paternalistic end of the care spectrum.
B. Guidance-cooperation occurs when the practitioner tells the patient what to do, and the patient complies with the instructions. This is common in acute infections where the doctor prescribes an antibiotic and the patient follows the regimen. While there is cooperation, it is not a true partnership, as the provider retains the majority of the decision-making power.
C. Mutual participation is the correct term for a partnership where the patient and practitioner work together as equals. This model is most effective for chronic disease management, such as diabetes, where the patient's daily choices are vital. It involves shared decision-making and recognizes the patient as an expert in their own life experience and health goals.
Correct Answer is B
Explanation
Debrox is an otic solution containing carbamide peroxide 6.5%, used primarily as an earwax (cerumen) removal aid. When applied to the ear canal, it releases oxygen, causing a foaming action that softens and loosens impacted wax. Proper administration is critical to avoid otic irritation or damage to the tympanic membrane. Treatment is generally limited to a specific duration before medical consultation is required.
Rationale:
A. True is incorrect because the specific dosage range and frequency provided do not match the standard FDA-approved labeling for this otic medication. While the medication is used for cerumen removal, the clinical guidelines dictate a higher drop count to ensure adequate saturation of the wax within the external auditory canal.
B. False is the correct answer because the standard adult dose for Debrox is 5 to 10 drops, not 1 to 5. The frequency is twice daily for up to 4 days. Providing only 1 to 5 drops may result in sub-therapeutic coverage, failing to effectively emulsify the impacted cerumen for subsequent irrigation.
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