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Introduction
Introduction ( 5 Questions)
A nurse is reviewing the mechanism of action of different antibiotic groups.
The nurse understands that which of the following antibiotics bind to the 30S ribosomal subunit of bacteria and interfere with protein synthesis?
Choice A is wrong because cefazolin (Zolicef) is a cephalosporin antibiotic that binds to the penicillin-binding proteins of bacteria and interferes with cell wall synthesis by inhibiting peptidoglycan cross-linking.
Amikacin (Amikin) is an aminoglycoside antibiotic that binds to the 30S ribosomal subunit of bacteria and interferes with protein synthesis by causing mRNA misreading and inhibiting 30S subunit assembly.
Choice C is wrong because ciprofloxacin (Cipro) is a fluoroquinolone antibiotic that binds to the DNA gyrase and topoisomerase IV of bacteria and interferes with DNA replication by inhibiting DNA supercoiling.
Choice D is wrong because penicillin G (Pfizerpen) is a beta-lactam antibiotic that binds to the penicillin-binding proteins of bacteria and interferes with cell wall synthesis by inhibiting peptidoglycan cross-linking.
Amikacin (Amikin) is an aminoglycoside antibiotic that binds to the 30S ribosomal subunit of bacteria and interferes with protein synthesis by causing mRNA misreading and inhibiting 30S subunit assembly.
Choice A is wrong because cefazolin (Zolicef) is a cephalosporin antibiotic that binds to the penicillin-binding proteins of bacteria and interferes with cell wall synthesis by inhibiting peptidoglycan cross-linking.
Choice C is wrong because ciprofloxacin (Cipro) is a fluoroquinolone antibiotic that binds to the DNA gyrase and topoisomerase IV of bacteria and interferes with DNA replication by inhibiting DNA supercoiling.
Choice D is wrong because penicillin G (Pfizerpen) is a beta-lactam antibiotic that binds to the penicillin-binding proteins of bacteria and interferes with cell wall synthesis by inhibiting peptidoglycan cross-linking.
Normal ranges for 30S ribosomal subunit are not applicable as it is a bacterial structure.
Normal ranges for antibiotics depend on the type, dose, route, frequency and duration of administration as well as the patient’s age, weight, renal function and infection site and severity.