Choice A rationale:

"Sickle cell disease results from a dominant genetic mutation.”.

This statement is not accurate.

Sickle cell disease is not caused by a dominant genetic mutation.

It is an autosomal recessive genetic disorder, meaning that both parents must pass on the mutated gene for the disease to manifest.

In this condition, a person must inherit two copies of the mutated HBB gene (one from each parent) to have sickle cell disease.

Choice B rationale:

"Both parents must pass on the mutated gene for sickle cell disease to manifest.”.

This is The correct answer.

Sickle cell disease is inherited in an autosomal recessive manner, which means that it only manifests when a person inherits two copies of the mutated HBB gene, one from each parent.

If only one copy of the gene is inherited, the individual is a carrier (sickle cell trait) and does not have the disease.

Choice C rationale:

"The mutation in the HBB gene leads to the production of normal hemoglobin.”.

This statement is incorrect.

The mutation in the HBB gene results in the production of abnormal hemoglobin, known as hemoglobin S (HbS).

This abnormal hemoglobin is responsible for the characteristic changes in red blood cells seen in sickle cell disease.

Choice D rationale:

"Sickle cell disease is inherited in an autosomal dominant manner.”.

This statement is also incorrect.

Sickle cell disease is not inherited in an autosomal dominant manner.

It is an autosomal recessive genetic disorder, as explained in Choice B.