A client is being screened for risk factors of depression. Which risk factor(s) is associated with the development of depression? (Select all that apply)
Current substance use
Lack of coping ability
Responsive support system
Prior episode(s) of depression
Family history of depressive disorder
Presence of life and environmental stressors
Correct Answer : A,B,D,E,F
Choice A reason: Current substance use is a well-established and clinically significant risk factor for the development and perpetuation of major depressive disorder. Substances including alcohol, opioids, stimulants, and cannabis have direct neurobiological effects on monoamine neurotransmitter systems, including serotonergic, dopaminergic, and noradrenergic pathways, which are central to mood regulation. Chronic substance use leads to dysregulation of these systems, neuroinflammation, and disruption of the hypothalamic-pituitary-adrenal (HPA) axis, all of which predispose to or worsen depressive symptomatology. Comorbid substance use disorder and major depressive disorder represent a highly prevalent and bidirectionally reinforcing dual diagnosis.
Choice B reason: A lack of coping ability is a recognized psychosocial risk factor for depressive disorders. Coping skills mediate the relationship between stressors and their psychological impact. Individuals who lack effective adaptive coping strategies — such as problem-solving, cognitive reframing, emotional regulation, and help-seeking — are more vulnerable to the persistent psychological distress that can precipitate and maintain clinical depression. Poor coping is associated with rumination, learned helplessness, and passive avoidance, all of which are cognitive and behavioral mechanisms strongly implicated in the etiology of depressive disorders. Building coping capacity is therefore a key component of both prevention and treatment.
Choice C reason: A responsive support system is a protective factor against the development of depression, not a risk factor. Social support buffers the negative psychological effects of stressful life events, provides emotional validation and practical assistance, reduces feelings of isolation, and promotes adaptive coping. Research consistently demonstrates that individuals with strong, responsive social support networks have significantly lower rates of major depressive disorder compared to those who are socially isolated. A responsive support system therefore does not belong among the risk factors associated with depression and is correctly excluded from the correct answer set.
Choice D reason: Prior episodes of depression represent one of the most robust and clinically significant risk factors for future depressive episodes. The concept of episode sensitization or "kindling" in affective disorders suggests that each successive episode of depression lowers the threshold for subsequent episodes, requiring progressively less severe external stressors to trigger recurrence. The number of previous episodes is directly correlated with recurrence risk, with individuals who have experienced 3 or more episodes of major depression having a recurrence rate exceeding 90%. This makes prior depressive episodes a critical factor in longitudinal risk assessment and treatment planning.
Choice E reason: A family history of depressive disorder is a well-established genetic and epidemiological risk factor for major depressive disorder. Twin studies estimate the heritability of major depression at approximately 37%, with first-degree relatives of individuals with MDD having a 2 to 3 times higher lifetime risk than the general population. The specific genetic variants implicated include polymorphisms in the serotonin transporter gene (SLC6A4), brain-derived neurotrophic factor (BDNF) gene, and genes related to the HPA axis and circadian regulation. Family history also contributes to risk through shared environmental exposures and modeled behavioral patterns, making it both a genetic and environmental risk factor.
Choice F reason: The presence of life and environmental stressors is a foundational risk factor in the biopsychosocial model of depression etiology. Adverse life events — including trauma, loss, financial hardship, interpersonal conflict, and occupational stress — activate the HPA axis, elevating cortisol levels and promoting neurobiological changes associated with depression, including hippocampal atrophy, reduced neurogenesis, and altered serotonergic and dopaminergic signaling. The diathesis-stress model proposes that environmental stressors interact with biological vulnerability to precipitate depressive episodes. Chronic and cumulative stressors are particularly harmful, as they sustain HPA axis activation beyond the individual's adaptive capacity.
Nursing Test Bank
Naxlex Comprehensive Predictor Exams
Related Questions
Correct Answer is D
Explanation
Choice A reason: Lecturing is a one-directional, didactic approach to communication that is particularly ineffective with clients diagnosed with antisocial personality disorder (ASPD). Individuals with ASPD characteristically exhibit pervasive disregard for rules and authority, lack of remorse, deceitfulness, and manipulative behavior. A lecturing approach tends to provoke power struggles, resentment, and non-compliance in this population, as it implies a hierarchical dynamic that clients with ASPD are likely to resist or exploit. Evidence-based nursing communication strategies for ASPD discourage moralistic or preachy approaches.
Choice B reason: Negotiation as a teaching strategy with clients diagnosed with ASPD is counterproductive because it inadvertently reinforces manipulative interpersonal dynamics. ASPD is characterized by a pervasive pattern of exploitation of others and disregard for social norms. Engaging in negotiation with such clients may be interpreted as flexibility in boundaries, which can be exploited. Consistent, firm, and clearly communicated boundaries are central to managing therapeutic relationships with clients with ASPD, and negotiation undermines the necessary therapeutic structure.
Choice C reason: A challenging approach, which involves directly confronting or questioning the client's statements or behaviors, is inappropriate for clients with ASPD. These individuals have low frustration tolerance and are prone to hostile or aggressive responses when they perceive a threat to their control or dominance. Challenging a client with ASPD may escalate agitation, provoke defensiveness, or stimulate manipulative countermeasures. Therapeutic communication guidelines for ASPD emphasize consistency, clear limit-setting, and avoiding emotional engagement in confrontational dynamics.
Choice D reason: A direct communication approach is the most therapeutically appropriate strategy for teaching clients with ASPD. Directness involves clear, concise, honest, and matter-of-fact communication without ambiguity, moralizing, or emotional appeal. Clients with ASPD respond best to clear statements about expectations, consequences, and information delivered in a factual and non-emotional manner. This approach minimizes opportunities for manipulation, reduces misinterpretation, establishes firm boundaries, and conveys mutual respect without encouraging power struggles. It is consistent with evidence-based psychiatric nursing guidelines for managing clients with Cluster B personality disorders.
Correct Answer is B
Explanation
Choice A reason: Challenging a client's behavior during an acute manic episode with threats of violence is a contraindicated and potentially dangerous nursing intervention. Clients in acute mania exhibit elevated irritability, impulsivity, poor impulse control, and a low threshold for aggressive responses when they perceive provocation or confrontation. Challenging behavior in this context risks escalating agitation and precipitating physical violence against staff, other clients, or property. Evidence-based de-escalation strategies for acute mania emphasize non-confrontational, calm, and structured communication rather than behavioral challenge, and standard psychiatric nursing guidelines consistently advise against confrontational approaches with acutely agitated clients.
Choice B reason: Ensuring safety is the overriding priority in this clinical scenario, consistent with both the nursing priority framework based on Maslow's hierarchy and the standards of psychiatric-mental health nursing practice. The client presents with acute mania, characterized by severely impaired judgment, psychomotor agitation, and explicit threats of physical violence toward household members. This constitutes an immediate risk of harm to others, which must be addressed before any other intervention. Safety encompasses protection of the client, staff, and third parties through environmental management, de-escalation, team communication, and, when necessary, pharmacological or physical interventions within the therapeutic and legal framework.
Choice C reason: Administering mood stabilizers, such as lithium carbonate, valproate (divalproex), or atypical antipsychotics such as quetiapine or olanzapine, is an essential component of the pharmacological management of acute mania in bipolar disorder. These agents reduce the severity and duration of manic episodes by modulating dopaminergic, serotonergic, and glutamatergic neurotransmission. However, mood stabilizers have a delayed onset of therapeutic effect, particularly lithium, which requires days to weeks to reach therapeutic serum levels. In the acute setting with immediate threats of violence, medication administration is a secondary intervention that supports safety goals but cannot be the first priority when immediate physical danger is present.
Choice D reason: Removing the client to a quiet, low-stimulation environment is a recognized and effective de-escalation strategy for managing acute mania, as excessive environmental stimuli can exacerbate psychomotor agitation and escalate behavioral dysregulation in manic episodes. Reducing sensory input — including noise, activity, and social stimulation — helps decrease arousal and facilitates de-escalation. However, environmental modification is a specific tactical intervention within the broader framework of ensuring safety. It addresses one dimension of the safety priority but is subordinate to the overarching goal of ensuring the physical safety of all individuals, including the client and potential victims of threatened violence.
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