A client undergoing chemotherapy develops severe abdominal pain, nausea, and a rapid increase in serum uric acid levels.
What is the most likely diagnosis?
Gastric ulcers.
Tumor lysis syndrome.
Acute kidney injury.
Gastroenteritis.
The Correct Answer is B
This scenario involves metabolic complications following chemotherapy for high-grade malignancies. Knowledge of intracellular electrolyte release, nucleic acid breakdown, and the resulting renal and systemic impacts is required to identify the specific oncological emergency occurring during rapid cell lysis.
Choice A rationale
Gastric ulcers cause abdominal pain and potential bleeding but do not account for a rapid increase in serum uric acid. Uric acid elevation is a systemic metabolic event related to DNA breakdown, whereas ulcers are localized mucosal erosions.
Choice B rationale
Tumor lysis syndrome occurs when chemotherapy causes rapid destruction of malignant cells, releasing intracellular contents. This leads to hyperuricemia, hyperkalemia, and hyperphosphatemia. High uric acid levels (above 6 mg/dL) can cause acute renal failure due to crystal formation.
Choice C rationale
While acute kidney injury may result from tumor lysis syndrome, it is a secondary consequence of the metabolic derangement. The primary diagnosis explaining the constellation of rapid uric acid rise and chemotherapy timing is the lysis syndrome.
Choice D rationale
Gastroenteritis causes nausea and abdominal pain but does not explain the significant metabolic shift of elevated uric acid. It is typically an infectious or inflammatory condition of the digestive tract, not a systemic response to cytotoxic therapy.
Nursing Test Bank
Naxlex Comprehensive Predictor Exams
Related Questions
Correct Answer is A
Explanation
Post-operative skin graft care focuses on maximizing graft take by reducing edema and preventing shearing. Knowledge of tissue perfusion and fluid dynamics is necessary to prioritize actions that minimize swelling, which can lift the graft from the bed.
Choice A rationale
Elevating the affected extremity reduces edema at the graft site by promoting venous return. Excessive swelling can separate the new graft from the underlying vascular bed, preventing necessary revascularization and leading to graft failure or necrosis.
Choice B rationale
Inspecting the graft site is important, but the nurse should generally not disturb the initial surgical dressing. Frequent inspection increases the risk of shearing or dislodging the delicate graft before it has successfully adhered to the site.
Choice C rationale
Ensuring the patient does not lie on the graft is a standard intervention to prevent pressure and shearing. However, in the presence of noted edema, elevation is the priority action to ensure the graft remains viable.
Choice D rationale
Administering analgesics addresses the pain level of 6/10, which is important for comfort. However, pain is expected, whereas reducing edema through elevation is functionally more critical to the physiological success and survival of the graft.
Correct Answer is A
Explanation
The nurse must utilize knowledge of thoracic drainage mechanics and equipment troubleshooting. A three-chamber system requires consistent suction to maintain negative pleural pressure. Identifying the cause of suction failure involves systematic assessment of the external vacuum source and tube integrity.
Choice A rationale
Suction control chambers in wet systems require active external suction to function. Bubbling indicates vacuum application. Verifying the regulator is on ensures the system has the mechanical force necessary to maintain the ordered negative pressure for lung re-expansion.
Choice B rationale
Milking or stripping chest tubes creates high levels of negative pressure that can damage delicate lung tissue. This practice is generally contraindicated unless specifically ordered by a surgeon, as it increases the risk of pleural trauma and tension pneumothorax.
Choice C rationale
Absence of bubbling in the suction control chamber of a wet system is an abnormal finding. It signifies a lack of active suctioning. The nurse cannot ignore this, as effective pleural drainage depends on continuous atmospheric pressure regulation.
Choice D rationale
While water levels dictate suction intensity, adding water will not resolve a lack of bubbling if the suction source is off. Bubbling is caused by air passing through water via the suction regulator, not the volume itself.
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