A nurse is administering an antifungal medication to a client who has a systemic fungal infection.
The nurse understands that antifungal drugs have a higher risk of toxicity than antibacterial drugs because:
fungi have cell walls that are difficult to penetrate.
fungi are more resistant to drug therapy than bacteria.
fungi and human cells have similar structures and functions.
fungi can mutate rapidly and develop drug resistance.
The Correct Answer is C
This means that antifungal drugs have to target specific components of the fungal cell that are different from the human cell, such as the cell membrane or the cell wall. However, this also increases the risk of toxicity to human cells, especially those that have high turnover rates, such as liver and kidney cells.
Choice A is wrong because fungi do not have cell walls that are difficult to penetrate. Fungi have cell walls that are composed of chitin, glucan, and mannoproteins, which are different from the peptidoglycan cell walls of bacteria.
Antifungal drugs can target these components and disrupt the integrity of the fungal cell wall.
Choice B is wrong because fungi are not more resistant to drug therapy than bacteria. Fungi can develop resistance to antifungal drugs, but this is not a common mechanism of antifungal drug failure. Bacteria can also develop resistance to antibacterial drugs through various mechanisms, such as producing enzymes that degrade or modify the drugs, altering the target sites of the drugs, or pumping out the drugs from the cell.
Choice D is wrong because fungi do not mutate rapidly and develop drug resistance.
Fungi have a slower rate of mutation than bacteria because they have a more complex genome and a more efficient DNA repair system
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Related Questions
Correct Answer is B
Explanation
This means that less of the drug will get into your bloodstream and it may not work as well to treat your infection.According to one source, dairy products can reduce the bioavailability of ciprofloxacin by 30 to 36 percent and the peak concentration by 36 percent.
Choice A is wrong because dairy products do not increase the risk of kidney stones with this medication.
There is no evidence to support this claim.
Choice C is wrong because dairy products do not cause allergic reactions with this medication.
Allergic reactions are possible with any medication, but they are not related to dairy products.
Choice D is wrong because dairy products do not interfere with the metabolism of this medication in your liver.
Ciprofloxacin is mainly eliminated by the kidneys, not the liver.
To avoid this interaction, you should take ciprofloxacin at least 2 hours before or 6 hours after dairy products.
Correct Answer is C
Explanation
This means that antifungal drugs have to target specific components of the fungal cell that are different from the human cell, such as the cell membrane or the cell wall.However, this also increases the risk of toxicity to human cells, especially those that have high turnover rates, such as liver and kidney cells.
Choice A is wrong because fungi do not have cell walls that are difficult to penetrate.Fungi have cell walls that are composed of chitin, glucan, and mannoproteins, which are different from the peptidoglycan cell walls of bacteria.
Antifungal drugs can target these components and disrupt the integrity of the fungal cell wall.
Choice B is wrong because fungi are not more resistant to drug therapy than bacteria.Fungi can develop resistance to antifungal drugs, but this is not a common mechanism of antifungal drug failure.Bacteria can also develop resistance to antibacterial drugs through various mechanisms, such as producing enzymes that degrade or modify the drugs, altering the target sites of the drugs, or pumping out the drugs from the cell.
Choice D is wrong because fungi do not mutate rapidly and develop drug resistance.
Fungi have a slower rate of mutation than bacteria because they have a more complex genome and a more efficient DNA repair system
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