A nurse is assessing a client who has hypercholesterolemia and is receiving simvastatin. Which of the following findings should the nurse recognize as a potential adverse effect?

Choice A reason: This is incorrect because dextrose 5% in 0.45% sodium chloride is a hypotonic solution that can cause hemolysis of the RBCs. It can also cause fluid shifts from the intravascular to the intracellular space, leading to edema and hypotension.

Choice B reason: This is correct because 0.9% sodium chloride is a isotonic solution that is compatible with blood products. It does not cause hemolysis or fluid shifts and maintains the osmotic pressure of the blood.

Choice C reason: This is incorrect because lactated Ringer's solution is a isotonic solution that contains electrolytes, such as potassium, calcium, and lactate, that can interfere with the blood products. It can also cause metabolic alkalosis due to the conversion of lactate to bicarbonate.

Choice D reason: This is incorrect because dextrose 5% in water is a hypotonic solution that can cause hemolysis of the RBCs. It can also cause fluid shifts from the intravascular to the intracellular space, leading to edema and hypotension.

Choice A reason: Taking the medication in the morning is not the correct instruction. Simvastatin is a statin drug that lowers cholesterol levels by inhibiting the enzyme that produces cholesterol in the liver. The liver produces more cholesterol at night, so simvastatin is more effective when taken in the evening or at bedtime.

Choice B reason: Avoiding grapefruit juice is the correct instruction. Grapefruit juice can increase the blood levels of simvastatin and cause serious side effects such as muscle damage, liver damage, and kidney failure. Grapefruit juice inhibits the enzyme that metabolizes simvastatin in the intestine, leading to higher concentrations of the drug in the bloodstream.

Choice C reason: Monitoring for ringing in the ears is not the correct instruction. Ringing in the ears, or tinnitus, is not a common or serious side effect of simvastatin. However, some other medications that lower cholesterol, such as niacin and gemfibrozil, can cause tinnitus. The client should report any unusual or persistent symptoms to the prescriber.

Choice D reason: Expecting brown-colored urine is not the correct instruction. Brown-colored urine, or hematuria, is not a normal or expected side effect of simvastatin. However, it may indicate a serious condition such as rhabdomyolysis, which is a rare but life-threatening complication of statin therapy. Rhabdomyolysis is the breakdown of muscle tissue that releases a protein called myoglobin into the bloodstream. Myoglobin can damage the kidneys and cause brown-colored urine. The client should seek immediate medical attention if they notice any signs of rhabdomyolysis, such as muscle pain, weakness, fever, or dark urine.