A nurse is reviewing the medical record of a male client who has schizophrenia and is taking clozapine. Which of the following findings should the nurse identify as a contraindication to the administration of clozapine?

A. The client’s symptoms (burning with urination, pain) and urinalysis findings are indicative of a urinary tract infection (UTI), which is typically caused by bacteria in the urinary tract. There are no clear indications of a vaginal infection (e.g., discharge, odor, or other symptoms specific to vaginal infections), so a vaginal culture is not needed for this clinical scenario.
B. The client’s symptoms and laboratory results (positive leukocyte esterase, WBC casts, cloudy urine) strongly suggest a UTI, and the elevated WBC count further confirms infection. Antibiotics are the primary treatment for a urinary tract infection. For pregnant clients, it is crucial to select antibiotics that are safe in pregnancy, as untreated UTIs can lead to preterm labor, kidney infections (pyelonephritis), and fetal complications.
C. Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID) that is generally contraindicated during pregnancy, especially in the third trimester, due to its potential for causing premature closure of the ductus arteriosus, renal complications, and increased bleeding risk. Alternative pain management strategies should be used in pregnancy.
D. Phenazopyridine is a urinary analgesic that can be used to relieve the pain, burning, and discomfort associated with UTIs. However, it is generally not recommended during pregnancy, especially in the first trimester, and should only be used in pregnancy if prescribed by a healthcare provider. There are potential concerns with the safety of phenazopyridine in pregnancy, and it should not be administered without a provider's approval.
E. A urine culture is a diagnostic test that can confirm the presence of a urinary tract infection and
identify the specific bacteria responsible for the infection. Given the client’s symptoms and positive findings on urinalysis, a urine culture should be obtained to help guide the choice of appropriate antibiotics. This will help ensure the effective treatment of the infection and prevent complications.

A. The client should be advised to limit the use of the affected hand, but complete rest for 4 to 6 weeks is often too long unless otherwise directed by the surgeon.
B. Ice, not heat, is recommended for pain and swelling in the first 24 hours post-surgery. Heat can exacerbate swelling.
C. Numbness and tingling should improve after surgery and not persist. If they do, it could indicate complications such as nerve damage.
D. Elevating the hand above the level of the heart helps reduce swelling and aids in the healing process after carpal tunnel surgery.