A patient asks the nurse to tell her more about a new drug the patient has been prescribed called ranolazine (Ranexa). Which response by the nurse is accurate?
This drug does not reduce blood pressure or heart rate.
This drug is a first-line therapy for angina.
This drug must be given intravenously.
Ranexa is safe to use in patients with liver failure.
The Correct Answer is A
Choice A rationale
Ranolazine (Ranexa) is an antianginal agent that works by inhibiting the late sodium current in cardiac myocytes. This inhibition leads to a reduction in intracellular calcium overload, improving myocardial relaxation and reducing ventricular wall tension. Unlike many other antianginal drugs, ranolazine does not significantly affect heart rate or blood pressure, making it useful in patients who cannot tolerate the hemodynamic effects of other agents.
Choice B rationale
Ranolazine is not a first-line therapy for angina. It is typically used as a second-line treatment in patients who have not achieved adequate symptom control with beta-blockers, calcium channel blockers, or nitrates. It is often prescribed in combination with other antianginal drugs.
Choice C rationale
Ranolazine is an oral medication available in an extended-release tablet formulation. It is not administered intravenously. The patient takes this medication by mouth, usually twice daily, for the long-term management of chronic angina.
Choice D rationale
Ranexa is metabolized by the liver, specifically via the cytochrome P450 3A (CYP3A) enzyme pathway. Therefore, it is contraindicated or requires significant dose adjustment in patients with moderate to severe hepatic impairment due to the risk of increased plasma concentrations and toxicity.
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Naxlex Comprehensive Predictor Exams
Related Questions
Correct Answer is C
Explanation
Choice A rationale
Dehydration is not a primary complication directly associated with beta-blocker use. Beta-blockers, such as propranolol or metoprolol, primarily affect the cardiovascular system by blocking beta-adrenergic receptors, which decreases heart rate and blood pressure. Dehydration is typically caused by inadequate fluid intake or excessive fluid loss from conditions like vomiting, diarrhea, or diuresis.
Choice B rationale
Hyperkalemia is an elevated potassium level, which is a rare side effect of non-selective beta-blockers, but not a primary complication to monitor for in a patient taking a beta-blocker for hypertension. Hyperkalemia is more commonly associated with conditions like renal failure or the use of certain medications, such as ACE inhibitors or potassium-sparing diuretics.
Choice C rationale
Beta-blockers can mask the physiological signs of hypoglycemia in patients with diabetes, such as tremors, palpitations, and tachycardia. This occurs because the drugs block the sympathetic nervous system's compensatory response to low blood glucose, which normally involves the release of epinephrine. Consequently, a patient may not recognize a hypoglycemic event until it becomes severe.
Choice D rationale
Angina is a symptom of myocardial ischemia, and beta-blockers are often used to prevent it, not cause it. By reducing the heart rate and contractility, beta-blockers decrease myocardial oxygen demand. This effect helps to prevent chest pain associated with angina, making it a therapeutic benefit rather than a potential complication.
Correct Answer is C
Explanation
Choice A rationale
While following the medication schedule strictly is a crucial part of medication administration, it is not the absolute priority. Administering a medication at the wrong time could potentially harm the patient if other checks are not performed first, highlighting that the core safety checks are the foremost priority.
Choice B rationale
Ensuring the patient takes the medication correctly is an important step in the process, but it follows the initial and more critical steps of verifying the medication and dose. If the incorrect drug is prepared or the wrong dose is calculated, the act of the patient taking it correctly becomes irrelevant and potentially dangerous.
Choice C rationale
The nurse's highest priority is to confirm the right medication, dose, route, and patient, as this practice, known as the "five rights," is the cornerstone of patient safety. This step minimizes the risk of administering the wrong drug, the wrong dose, or to the wrong patient, which could lead to severe adverse outcomes.
Choice D rationale
Documentation is a vital part of the medication administration process for legal and continuity of care purposes, but it must be done after the medication has been administered. Documenting before the action is completed can lead to errors and is not considered a safe practice, therefore it cannot be the priority.
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