A woman who is 32 weeks pregnant presents to the clinic. The nurse suspects preeclampsia. Which of the following findings support this diagnosis? (Select All that Apply.)

A. Rho(D) immune globulin (RhoGAM) is indicated when an Rh-negative mother gives birth to an Rh-positive infant. This prevents the mother’s immune system from developing antibodies against Rh-positive blood cells, which could cause hemolytic disease of the newborn (HDN) in future pregnancies.

B. An Rh-positive mother already has the D antigen, so she will not form antibodies against an Rh-negative baby. RhoGAM is not needed.

C. The mother is Rh-positive and cannot develop antibodies against Rh-positive fetal blood cells. No RhoGAM is required.

D. Both mother and baby are Rh-negative, so there is no risk of maternal sensitization. RhoGAM is not indicated.

A. EMLA cream is a pharmacologic intervention because it contains local anesthetics (lidocaine and prilocaine) that numb the skin. It must be applied 30–60 minutes before the procedure under an occlusive dressing to achieve effective analgesia. Applying it immediately before a heel stick would not provide pain relief and does not qualify as nonpharmacologic.

B. Intramuscular opioids are systemic pharmacologic agents used for moderate to severe pain. They carry risks such as respiratory depression, sedation, and hypotension in neonates, so they are rarely used for minor procedures like heel sticks.

C. Distraction with toys or verbal explanations is ineffective for neonates because infants at 2 days old cannot process or respond to visual or verbal cues. Cognitive engagement strategies work only in older infants and children.

D. Oral sucrose combined with nonnutritive sucking (e.g., using a pacifier) is a safe and evidence-based nonpharmacologic method for reducing procedural pain in neonates. Sucrose triggers the release of endogenous opioids in the central nervous system, which decreases the perception of pain. Nonnutritive sucking provides comfort and a calming effect, further reducing physiological stress responses such as increased heart rate, blood pressure, and crying. Studies show that this intervention effectively lowers behavioral and physiological indicators of pain during minor procedures such as heel sticks, venipuncture, or immunizations. This method is preferred for routine procedures in neonates because it is simple, safe, and effective without the risks associated with pharmacologic agents.