All the following medications are ordered for a mechanically ventilated patient with acute respiratory distress syndrome (ARDS) and acute renal failure.
Which medication should the nurse discuss with the health care provider before administration?
IV gentamicin (Garamycin) 60 mg.
Sucralfate (Carafate) 1 g per nasogastric tube.
IV ranitidine (Zantac) 50 mg IV.
IV methylprednisolone (Solu-Medrol) 40 mg.
The Correct Answer is A
Choice A rationale
Gentamicin is an aminoglycoside antibiotic known for its significant nephrotoxic and ototoxic side effects. In a patient with acute renal failure, the clearance of gentamicin is severely impaired because it is primarily excreted unchanged by the kidneys. Normal serum creatinine is 0.7 to 1.3 mg/dL. Administering a standard dose to a patient with failing kidneys can lead to toxic accumulation, further worsening renal damage. The nurse must verify dose adjustments or alternative therapies with the provider.
Choice B rationale
Sucralfate is a mucosal protectant used to prevent stress ulcers in mechanically ventilated patients. It works locally by forming a protective barrier over gastric erosions and does not require significant renal clearance or systemic absorption. While it can interfere with the absorption of other drugs, it is generally considered safe for patients with renal failure. It is a standard prophylactic measure in the intensive care unit to prevent gastrointestinal bleeding during periods of physiological stress like ARDS.
Choice C rationale
Ranitidine is an H2-receptor antagonist used to reduce gastric acid secretion and prevent stress-induced gastritis. While some dose adjustment may be necessary in severe renal impairment, it does not possess the high level of acute nephrotoxicity seen with aminoglycosides. It is frequently used in critically ill patients to maintain a gastric pH above 4.0. Its use in this patient is common practice, and while monitoring is required, it does not pose the immediate threat that gentamicin does.
Choice D rationale
Methylprednisolone is a corticosteroid used in the fibroproliferative phase of ARDS to reduce pulmonary inflammation and improve oxygenation. It is metabolized primarily by the liver rather than the kidneys. Therefore, acute renal failure does not significantly alter its clearance or increase the risk of acute toxicity in the same manner as renally excreted antibiotics. It is a vital component of the inflammatory management for ARDS and would not typically require an urgent consultation.
Nursing Test Bank
Naxlex Comprehensive Predictor Exams
Related Questions
Correct Answer is D
Explanation
Choice A rationale
Coughing and deep breathing are nursing interventions typically used to prevent atelectasis and pneumonia, but they are contraindicated in patients with increased intracranial pressure. The act of coughing causes a sudden, sharp increase in intrathoracic and intra-abdominal pressure, which is transmitted to the cranial vault through the venous system. This transient spike in pressure can further compromise cerebral perfusion and potentially lead to brain herniation in a patient who is already neurologically vulnerable.
Choice B rationale
Hyperthermia increases the cerebral metabolic rate and oxygen demand, which can exacerbate brain injury. However, applying a warming blanket is generally not indicated unless the patient is hypothermic. In the context of increased intracranial pressure, maintaining a cool or normothermic environment is preferred to reduce metabolic requirements. Using a warming blanket unnecessarily could lead to vasodilation and increased cerebral blood flow, which may inadvertently raise the pressure within the rigid confines of the skull.
Choice C rationale
Positioning a client in a supine position is detrimental when intracranial pressure is elevated. A flat position hinders venous drainage from the brain through the jugular veins, leading to venous congestion and a subsequent rise in intracranial volume. The standard of care is to elevate the head of the bed to at least 30 degrees. This utilize gravity to enhance venous outflow, thereby helping to reduce the overall pressure and improve the clinical status of the patient.
Choice D rationale
Log rolling is the safest method to reposition a patient with a head or spinal injury because it maintains the head and neck in a neutral, midline alignment. Maintaining midline alignment is crucial because extreme neck flexion or rotation can obstruct the jugular veins and impede venous return from the brain. By ensuring the head does not turn independently of the body, the nurse prevents unnecessary increases in intracranial pressure while attending to the patient's skin integrity.
Correct Answer is C
Explanation
Choice A rationale
While reducing environmental stimuli like light and noise can help decrease agitation in some patients, it does not address the potentially life-threatening physiological causes of restlessness. Restlessness in a mechanically ventilated patient is a primary clinical indicator of hypoxemia or hypercapnia. Failing to assess the patient's oxygenation status first could lead to a delay in recognizing respiratory failure or ventilator malfunction, which could result in permanent organ damage or cardiac arrest.
Choice B rationale
Documentation is a vital part of nursing care, but it must follow a thorough assessment and appropriate intervention. Restlessness is a significant change in clinical status for a ventilated patient and should never be the only action taken. Ignoring the underlying cause of the behavior and simply recording it in the medical record is a failure of nursing judgment that puts the patient at risk for undetected respiratory distress or unplanned self-extubation.
Choice C rationale
Pulse oximetry provides a non-invasive, rapid assessment of the patient's arterial oxygen saturation, with a normal range typically being 95 to 100 percent. Restlessness is often the very first sign of hypoxia as the brain responds to decreased oxygen levels. By checking the saturation immediately, the nurse can determine if the restlessness is due to a physiological need for more oxygen, a dislodged tube, or a need for suctioning before considering psychological or environmental factors.
Choice D rationale
Administering sedation or analgesics to a restless patient without first assessing their respiratory status is dangerous. If the restlessness is caused by hypoxia, adding a sedative will further depress the respiratory drive and mask the clinical signs of distress, leading to a rapid decline in the patient's condition. While comfort is important, the nurse must prioritize the "Airway, Breathing, and Circulation" (ABC) framework and confirm adequate gas exchange before providing any pharmacological chemical restraints.
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