An 18-year-old male is taking Hydroxyurea for treatment of sickle cell anemia. Which options below indicate this medication is working successfully?

The patient experiences a decrease in hemoglobin S.

The patient experiences dehydration due to diuresis

The patient experiences an increase in fetal hemoglobin (Hbg F)

The patient needs fewer blood transfusions.

The patient experiences diuresis

Answer and Explanation

Correct Answer : C,D

A.   The patient experiences a decrease in hemoglobin S. Hydroxyurea does not decrease hemoglobin S levels directly; it works by increasing fetal hemoglobin (Hgb F) levels.
B.   The patient experiences dehydration due to diuresis. This is not an indication that Hydroxyurea is working; it is a potential side effect that should be monitored.
C.   The patient experiences an increase in fetal hemoglobin (Hbg F). Hydroxyurea works by increasing the levels of fetal hemoglobin, which reduces the sickling of red blood cells.
D.   The patient needs fewer blood transfusions. Successful treatment with Hydroxyurea should reduce the frequency of vaso-occlusive crises and the need for blood transfusions.
E.   The patient experiences diuresis. This is not an indicator of the medication's effectiveness; it is a potential side effect.

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Correct Answer is C

Explanation

A. Gastrointestinal bleeding is a common source of chronic blood loss leading to iron deficiency anemia.
B. Peptic ulcers can cause chronic gastrointestinal bleeding, contributing to iron deficiency.
C. Loss of intrinsic factor leads to vitamin B12 deficiency and pernicious anemia, not iron deficiency.
D. Genitourinary bleeding is another potential source of chronic blood loss that can result in iron deficiency anemia.

A. Severe pain B. Fever C. Normal blood counts D. Clear urine E. Increased energy levels F. Normal oxygen saturation levels G. Jaundice

Correct Answer is ["A","B","G"]

Explanation

A. Severe pain is a hallmark manifestation of a sickle cell crisis due to vaso-occlusion and tissue ischemia.
B. Fever can occur during a sickle cell crisis, often indicating an underlying infection or inflammatory response.
C. Normal blood counts are not typical during a sickle cell crisis; patients often exhibit anemia, leukocytosis, and thrombocytosis.
D. Clear urine is not a common manifestation of a sickle cell crisis; hematuria or dark-colored urine may occur due to hemolysis or kidney damage.
E. Increased energy levels are not typical during a sickle cell crisis; patients often experience fatigue and malaise.
F. Normal oxygen saturation levels may occur in some patients during a sickle cell crisis, but it is not a consistent finding.
G. Jaundice is common in sickle cell crisis due to hemolysis of red blood cells, leading to an increase in bilirubin levels.

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An 18-year-old male is taking Hydroxyurea for treatment of sickle cell anemia. Which options below indicate this medication is working successfully?

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Naxlex Comprehensive Predictor Exams

Blood loss is a major cause of iron deficiency in adults. Some sources of chronic blood loss in adults are all except:

Correct Answer is C

Explanation

Which of the following are common manifestations of a sickle cell crisis? (Select all that apply)

Correct Answer is ["A","B","G"]

Explanation

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