An 83-year-old man presents to the community behavioral health clinic, where he is diagnosed with Alzheimer's disease by the PMHNP. He currently smokes two packs of cigarettes a day and declines help with smoking cessation. Which medication for Alzheimer's disease is contraindicated in this patient due to smoking status?
None
Galantamine (Razadyne)
Donepezil (Aricept)
Rivastigmine (Exelon)
The Correct Answer is B
Choice A reason: "None" is incorrect because certain medications can interact with metabolic pathways affected by smoking.
Choice B reason: Galantamine is metabolized by the CYP1A2 enzyme, which is induced by smoking. This induction can reduce therapeutic levels of the drug, potentially making it less effective or requiring dose adjustment, thus contraindicating its use without careful monitoring.
Choice C reason: Donepezil is metabolized primarily by CYP2D6 and CYP3A4 and is not significantly affected by smoking; it remains safe for use in smokers.
Choice D reason: Rivastigmine is metabolized by esterases, not CYP enzymes, so smoking does not alter its metabolism, making it safe in this patient.
Nursing Test Bank
Naxlex Comprehensive Predictor Exams
Related Questions
Correct Answer is B
Explanation
Choice A reason: Providing limited information without consent still breaches patient confidentiality and legal protections under HIPAA.
Choice B reason: The patient, being 18, is legally an adult and has the right to confidentiality regarding her medical and psychiatric care. Consent must be obtained before sharing any information.
Choice C reason: Health insurance coverage does not give a parent the right to access a patient’s medical details; legal protections ensure patient privacy.
Choice D reason: Telling the father to make an appointment does not resolve the confidentiality issue and could lead to inappropriate disclosure.
Correct Answer is B
Explanation
Choice A reason: The triglyceride triad refers to elevated triglycerides, small dense LDL, and low HDL, which is part of metabolic syndrome but not the overall term.
Choice B reason: Metabolic syndrome is the correct term encompassing obesity, insulin resistance, dyslipidemia, and hypertension, which collectively increase the risk of cardiovascular disease, diabetes, and stroke.
Choice C reason: Cardiovascular cluster is not a standardized medical term.
Choice D reason: Endocrine failure refers to organ-specific hormonal insufficiency and is unrelated to metabolic syndrome.
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