(Select All That Apply): A nurse is providing care for a client with suspected major depressive disorder (MDD). Which of the following are risk factors for developing MDD? Select all that apply.

Choice A rationale:

Genetic theory suggests that a person's genetic makeup can predispose them to develop depression, but it does not specifically address the role of neurotransmitters in depression. While genetics can contribute to the risk of major depressive disorder (MDD), this choice doesn't focus on the neurotransmitter imbalances.

Choice B rationale:

Neuroendocrine theory pertains to the role of hormones in depression, particularly abnormalities in the hypothalamic-pituitary-adrenal (HPA) axis. While hormones play a role in mood regulation, this theory does not primarily revolve around neurotransmitter imbalances.

Choice C rationale:

Neurotransmitter theory proposes that an imbalance of neurotransmitters, such as serotonin, norepinephrine, and dopamine, contributes to the development of major depressive disorder. This theory aligns with the idea that these neurotransmitters are responsible for regulating mood, motivation, reward, cognition, and stress response.

Choice D rationale:

Environmental theory suggests that external factors, such as life events and stressors, contribute to the development of depression. While environment can indeed influence depression, it does not specifically address the neurotransmitter imbalances that are central to this question.

Choice A rationale:

The correct answer. A positive family history of mood disorders is a well-established risk factor for developing major depressive disorder (MDD). Genetic factors play a significant role in predisposing individuals to MDD, making it more likely to develop if there's a family history of mood disorders.

Choice B rationale:

Optimistic personality traits are not considered risk factors for developing major depressive disorder (MDD). In fact, having an optimistic personality might serve as a protective factor against developing MDD.

Choice C rationale:

The correct answer. Young age is a risk factor for developing MDD. Adolescents and young adults are particularly susceptible to the onset of depressive disorders due to hormonal changes, emotional challenges, and life transitions during this developmental stage.

Choice D rationale:

High socioeconomic status is not a consistent risk factor for developing major depressive disorder (MDD). While individuals from various socioeconomic backgrounds can develop MDD, the factors contributing to its development are more complex and not solely dependent on socioeconomic status.

Choice E rationale:

The correct answer. Chronic medical conditions are risk factors for developing major depressive disorder (MDD). The stress, emotional toll, and physiological effects of living with a chronic illness can contribute to the onset or exacerbation of depressive symptoms.