The healthcare provider has decreased the dosage of a medication for a client who is malnourished. What is the nurse's correct understanding of the rationale for this action by the healthcare provider?
Higher amounts of free drug in the body may lead to toxicity.
Since the body's metabolism is slower, less drug is required.
Serum protein levels are higher than normal, requiring less medication.
The action is not correct since a malnourished person requires more medication to be effective.
The Correct Answer is A
A. Higher amounts of free drug in the body may lead to toxicity: Many medications are highly protein-bound, primarily to albumin. Malnutrition causes hypoalbuminemia, leaving fewer binding sites available for the drug molecules. This increases the concentration of pharmacologically active "free" drug, significantly elevating the risk of toxic effects.
B. Since the body's metabolism is slower, less drug is required: While metabolic rates may fluctuate, the primary concern in malnutrition is the change in drug distribution and protein binding. Decreased hepatic enzyme activity may occur, but the immediate risk stems from high free drug levels. Protein availability is the dominant pharmacokinetic factor here.
C. Serum protein levels are higher than normal, requiring less medication: Malnutrition is characterized by protein-energy deficits, which lead to decreased serum albumin and total protein levels. Higher protein levels would actually lead to more drug binding and less free drug. This choice contradicts the physiological reality of the malnourished state.
D. The action is not correct since a malnourished person requires more medication to be effective: Increasing the dose for a malnourished client would be dangerous and potentially lethal. With fewer transport proteins, even standard doses can become toxic. Reducing the dose is a necessary safety precaution to account for increased drug bioavailability.
Nursing Test Bank
Naxlex Comprehensive Predictor Exams
Related Questions
Correct Answer is ["1.25"]
Explanation
Dose prescribed /Dose available=Amount to administer
25mg20mg/ml=1.25ml
Correct Answer is B
Explanation
A. Hemorrhage: This complication involves acute, profuse blood loss from damaged vascular structures within the surgical site. Clinical manifestations typically include hematoma formation, hypovolemia, or bright red sanguineous output. The presence of intact edges and serosanguinous fluid contradicts active arterial or venous bleeding.
B. Wound infection: Pathogenic colonization triggers an inflammatory response characterized by localized erythema and edema around the incision. Increased serosanguinous or purulent exudate reflects the body's immunological reaction to microbial invasion. These clinical markers are classic precursors to localized sepsis or abscess formation.
C. Wound dehiscence: This mechanical failure involves the partial or total separation of previously approximated wound layers. While serosanguinous drainage can precede this event, the question specifically states the incision edges remain intact. Therefore, the structural integrity of the wound has not yet been compromised.
D. Fistula development: This represents the formation of an abnormal passage between two internal organs or an organ and the skin. It usually results from chronic inflammation, malignancy, or severe infection rather than acute post-operative edema. The localized symptoms described are more indicative of a superficial or deep infection.
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