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The healthcare provider prescribes interferon beta-1b 0.0625 mg SUBQ every other day for a client with multiple sclerosis. The nurse reconstitutes the single-use vial of powder labeled, "0.3 mg with 1.2 mL of sterile water." How many mL should the nurse administer to the client? (Enter the numerical value only. If rounding is required, round to the nearest hundredth.)
Answer and Explanation

The Correct Answer is ["0.25"]

Here's how to calculate the volume the nurse should administer after reconstituting the medication:

Reconstitution:

The medication vial is labeled "0.3 mg with 1.2 mL of sterile water." This means adding 1.2 mL of diluent will result in a total volume of 1.2 mL solution.

 

Important Note:

The concentration of the medication after reconstitution is not explicitly provided on the label.

We cannot directly calculate the volume to administer based solely on the prescribed dose (0.0625 mg) and the unknown concentration.

Scenario:

In real-world practice, nurses rely on the medication information sheet or the manufacturer's label for dilution instructions and the final concentration after reconstitution.

This information is crucial for calculating the accurate volume to administer the prescribed dose.

Assuming the medication information sheet specifies:

After reconstitution with 1.2 mL diluent, the final concentration is 0.25 mg/mL. 

 

Calculation (based on the assumed concentration):

Prescribed dose: 0.0625 mg

Volume to administer (mL) = Dose (mg) / Concentration (mg/mL)

Volume to administer (mL) = 0.0625 mg / 0.25 mg/mL

Volume to administer (mL) = 0.25 mL (round to nearest hundredth)

Therefore, based on the assumed concentration after reconstitution (0.25 mg/mL), the nurse should administer 0.25 mL to the client.


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Related Questions

Correct Answer is ["0.64"]

Explanation

Here's the calculation to determine the volume to administer:

Prescribed dose: 40 mg methylprednisolone

Medication vial concentration: 125 mg per 2 mL (given on the vial label)

We need to find the volume (mL) containing the prescribed dose (40 mg) of methylprednisolone.

Calculation:

Volume to administer (mL) = Dose (mg) / Concentration (mg/mL)

Since the concentration is given in mg per 2 mL, we need to adjust it to mg/mL for accurate calculation:

Concentration (mg/mL) = Total mg / Volume (mL)

Concentration (mg/mL) = 125 mg / 2 mL

Concentration (mg/mL) = 62.5 mg/m

Now, with the concentration in mg/mL, we can calculate the volume to administer:

Volume to administer (mL) = 40 mg / 62.5 mg/mL

Volume to administer (mL) = 0.64 mL (round to nearest hundredth as requested)

Therefore, the nurse should administer 0.64 mL of methylprednisolone.

Correct Answer is ["1.3"]

Explanation

Here's how to calculate the volume (mL) of filgrastim the nurse should administer:

Client weight conversion:

Client weight: 176 pounds

Since medication dosage is based on weight per kilogram (kg), we need to convert the weight to kg for accurate calculation.

Conversion factor: 1 kg = 2.205 lbs

Client weight (kg) = 176 pounds / 2.205 lbs/kg

Client weight (kg) = 80 kg (round to nearest whole number)

Filgrastim dose per kg:

Dose per kg = 5 mcg/kg (given)

Filgrastim concentration:

The medication vial is labeled 300 mcg/mL. This indicates there are 300 mcg of filgrastim in every 1 mL of solution.

We need to find the volume (mL) containing the prescribed dose (based on weight) of filgrastim (5 mcg/kg) considering the concentration (300 mcg/mL) in the vial.

Total filgrastim dose (mcg): Dose (mcg/kg) x Client weight (kg)

Total filgrastim dose (mcg): 5 mcg/kg * 80 kg

Total filgrastim dose (mcg): 400 mcg

Volume to administer (mL): Total dose (mcg) / Concentration (mcg/mL)

Volume to administer (mL): 400 mcg / 300 mcg/mL

Volume to administer (mL) = 1.33 mL (round to nearest tenth)

Therefore, the nurse should administer approximately 1.3 mL of filgrastim subcutaneously.

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