What is the antidote for dabigatran?
Vitamin K
Activated charcoal
Idarucizumab
Andexanet alfa
The Correct Answer is C
A. Vitamin K: Vitamin K is used to reverse the effects of warfarin by promoting clotting factor synthesis. It is ineffective against dabigatran, a direct thrombin inhibitor, because dabigatran’s mechanism is independent of vitamin K–dependent clotting factors.
B. Activated charcoal: Activated charcoal can reduce the absorption of recently ingested dabigatran if given within a short timeframe after ingestion. However, it is not a specific antidote and is only useful in cases of recent overdose, not for urgent reversal in bleeding emergencies.
C. Idarucizumab: Idarucizumab is a monoclonal antibody fragment that specifically binds to dabigatran, neutralizing its anticoagulant effect. It acts rapidly and is indicated in life-threatening or uncontrolled bleeding or when urgent surgery is required, making it the definitive antidote.
D. Andexanet alfa: Andexanet alfa is an antidote for factor Xa inhibitors such as apixaban and rivaroxaban. It does not reverse dabigatran, which is a direct thrombin inhibitor, and therefore is not appropriate.
Nursing Test Bank
Naxlex Comprehensive Predictor Exams
Related Questions
Correct Answer is D
Explanation
A. Lethargy: Lethargy is not typically associated with overuse of albuterol. Albuterol is a beta-2 agonist that primarily stimulates the sympathetic nervous system, which usually increases alertness rather than causing sedation.
B. Weight gain: Weight gain is not a known side effect of albuterol overuse. Albuterol’s effects are more acute and related to cardiovascular and respiratory systems rather than fluid retention or metabolic changes that cause weight gain.
C. Hypotension: Albuterol can cause mild vasodilation, but hypotension is not a common clinical finding with overuse. Instead, sympathetic stimulation often leads to increased heart rate and blood pressure fluctuations rather than consistent low blood pressure.
D. Tachycardia: Overuse of albuterol can lead to tachycardia because it stimulates beta-1 receptors in the heart along with beta-2 receptors in the lungs. Frequent use may indicate poor asthma control and can manifest as palpitations, elevated heart rate, and potential arrhythmias.
Correct Answer is C
Explanation
A. Red blood cells: While red blood cell counts provide information about oxygen-carrying capacity and anemia, they do not directly reflect the anticoagulant effect of heparin or the risk of bleeding due to its use. Monitoring RBCs is not sufficient for safe heparin therapy.
B. International normalized ratio (INR): INR is primarily used to monitor warfarin therapy, not heparin. It measures the extrinsic pathway of coagulation, whereas heparin affects the intrinsic pathway, so INR is not the appropriate laboratory value for heparin monitoring.
C. Partial thromboplastin time (PTT): PTT measures the effectiveness of the intrinsic and common coagulation pathways, which are directly affected by heparin. Monitoring PTT helps ensure that the client maintains a therapeutic anticoagulation range and reduces the risk of bleeding or clot formation.
D. Hematocrit: Hematocrit reflects the proportion of red blood cells in the blood and can indicate blood loss over time. While important for general assessment, it does not specifically monitor heparin’s anticoagulant effect and is not the primary lab value to guide dosing.
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