What is the generic name of Augmentin?
Piperacillin with Tazobactam
Amoxicillin with Clavulanate Potassium
Metronidazole
Sulfamethoxazole with Trimethoprim
The Correct Answer is B
A. Piperacillin with tazobactam is a parenteral antipseudomonal penicillin combination marketed under the brand Zosyn. It is used for severe systemic infections involving Pseudomonas aeruginosa. It is not the generic composition of the oral medication known as Augmentin.
B. Augmentin is the brand name for amoxicillin with clavulanate potassium. Amoxicillin is a beta-lactam antibiotic that inhibits cell wall synthesis. Clavulanate acts as a beta-lactamase inhibitor, preventing the enzymatic degradation of amoxicillin by resistant bacterial strains.
C. Metronidazole is a nitroimidazole antimicrobial used for anaerobic infections and protozoal diseases. It functions by creating reactive free radicals that disrupt bacterial DNA. It is a single-agent generic medication and is not the active component of Augmentin.
D. Sulfamethoxazole with trimethoprim is a sulfonamide combination marketed under the brand Bactrim or Septra. This drug inhibits two consecutive steps in the bacterial folic acid synthesis pathway. It represents a different pharmacological class than the penicillin-based Augmentin.
Nursing Test Bank
Naxlex Comprehensive Predictor Exams
Related Questions
Correct Answer is C
Explanation
A. Rizatriptan is the active pharmaceutical ingredient for the brand Maxalt. While it belongs to the same selective 5-hydroxytryptamine 1B and 1D receptor agonist class, it is not the chemical constituent of Imitrex. It possesses a different pharmacokinetic profile.
B. Almotriptan is the generic name for the brand Axert. This compound is indicated for the acute treatment of migraine with or without aura in adults. It is a separate molecular entity from the drug requested in the question stem.
C. Sumatriptan is the generic name for Imitrex, the first triptan developed for clinical use. It acts as a selective agonist at vascular 5-HT1B and 5-HT1D receptors. This binding induces cranial vessel vasoconstriction and inhibits the release of proinflammatory neuropeptides.
D. Eletriptan is marketed under the brand name Relpax. It is a second-generation triptan used for migraine abortive therapy. It is not the active ingredient in Imitrex. Its metabolism and bioavailability differ significantly from those of sumatriptan.
Correct Answer is C
Explanation
A. MS Contin is the brand name for morphine sulfate extended-release, a potent opioid analgesic. It functions as a pure mu-opioid receptor agonist to modulate the perception of pain. It is not chemically related to the sulfonamide-derived compound celecoxib.
B. Voltaren is the brand name for diclofenac, a non-selective nonsteroidal anti-inflammatory drug. It inhibits both cyclooxygenase-1 and cyclooxygenase-2 enzymes to reduce prostaglandin synthesis. Celecoxib is a distinct pharmaceutical agent with a different selectivity profile than diclofenac.
C. Celebrex is the brand name for celecoxib, a selective cyclooxygenase-2 inhibitor. It primarily targets the inducible isoform of the cyclooxygenase enzyme to decrease inflammatory prostaglandin production. This specificity reduces the incidence of gastrointestinal toxicity compared to non-selective agents.
D. Motrin is the brand name for ibuprofen, a propionic acid derivative and non-selective nonsteroidal anti-inflammatory drug. It provides analgesic and antipyretic effects by inhibiting both cyclooxygenase isoforms. It is not the proprietary name for the selective inhibitor celecoxib.
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