When giving antihypertensive drugs, the nurse will consider giving the first dose at bedtime for which class of drugs?
Alpha blockers such as doxazosin (Cardura)
Diuretics such as furosemide (Lasix)
ACE inhibitors such as captopril (Capoten)
Vasodilators such as hydralazine (Apresoline)
The Correct Answer is A
Alpha blockers such as doxazosin (Cardura) are known to cause a pronounced first-dose orthostatic hypotensive effect, especially after the initial administration. This sudden drop in blood pressure can result in dizziness, syncope, or fainting, particularly when moving from lying to standing. Administering the first dose at bedtime helps minimize the risk of injury from falls or fainting episodes during this adjustment period.
Rationale for correct answer:
A. Alpha blockers such as doxazosin (Cardura):
Alpha-adrenergic blockers work by causing vasodilation through the relaxation of smooth muscle in blood vessels, leading to a decrease in peripheral vascular resistance. However, the initial dose can cause a marked drop in blood pressure, known as the “first-dose phenomenon.” Giving the first dose at bedtime helps reduce the client’s risk of falling or fainting, as they are in a supine position when the drug takes effect.
Rationales for incorrect answers:
B. Diuretics such as furosemide (Lasix):
Diuretics increase urine output, which can lead to nocturia if taken at bedtime. Therefore, they are typically administered in the morning to prevent nighttime interruptions and maintain patient safety.
C. ACE inhibitors such as captopril (Capoten):
Although ACE inhibitors can cause hypotension, especially after the first dose, the effect is generally less abrupt than that seen with alpha blockers. Timing of administration is flexible and not specifically recommended at bedtime unless the client experiences dizziness.
D. Vasodilators such as hydralazine (Apresoline):
Vasodilators may cause hypotension, but the first-dose phenomenon is not as pronounced as with alpha blockers. These drugs are usually given as scheduled, with blood pressure monitoring rather than timing adjustment.
Take-home points:
• Alpha blockers cause a marked first-dose hypotensive effect, requiring the initial dose to be given at bedtime.
• Administering the first dose at night reduces the risk of dizziness, syncope, and falls.
• Monitor blood pressure closely after the first dose and educate patients to rise slowly from bed or sitting positions.
Nursing Test Bank
Naxlex Comprehensive Predictor Exams
Related Questions
Correct Answer is A
Explanation
Propranolol (Inderal) is a non-selective beta-adrenergic blocker used to manage hypertension, angina, and arrhythmias. It works by blocking both beta-1 and beta-2 receptors, which reduces heart rate and cardiac output. However, blocking beta-2 receptors in the lungs causes bronchoconstriction, making this drug contraindicated in clients with asthma or other obstructive pulmonary diseases.
Rationale for correct answer:
A. Asthma
Propranolol blocks beta-2 receptors in bronchial smooth muscle, leading to bronchospasm and airway constriction, which can precipitate a life-threatening asthma attack. For clients with asthma or COPD, a cardioselective beta-blocker (like metoprolol or atenolol) is preferred, as these primarily target beta-1 receptors in the heart with less effect on the lungs.
Rationales for incorrect answers:
B. Diabetes
Although propranolol can mask symptoms of hypoglycemia such as tachycardia, it is not an absolute contraindication. Caution is needed, and diabetic clients should monitor their blood glucose closely.
C. Angina
Propranolol is commonly prescribed to treat angina pectoris because it reduces myocardial oxygen demand by lowering heart rate and contractility. It is not contraindicated for this condition.
D. Tachycardia
Propranolol is often used to control tachycardia, especially those related to anxiety or hyperthyroidism, by decreasing sympathetic stimulation of the heart. It is therefore therapeutic, not contraindicated.
Take-home points:
- Propranolol is contraindicated in clients with asthma due to the risk of bronchospasm.
- Non-selective beta-blockers affect both the heart and lungs, whereas cardioselective ones primarily target the heart.
- Clients with diabetes taking propranolol require careful glucose monitoring because symptoms of hypoglycemia can be masked.
Correct Answer is A
Explanation
For clients with hypertension, lifestyle modifications remain essential even after starting on medication therapy. Pharmacologic treatment is often necessary when lifestyle measures alone are insufficient, but it does not replace them. Combining drug therapy with lifestyle changes such as diet modification, weight control, physical activity, and smoking cessation provides the best long-term control of blood pressure and prevention of complications such as stroke, myocardial infarction, and renal damage.
Rationale for correct answer:
A. “I figure that since I have started on these medications that I don’t have to follow those lifestyle modifications anymore.”
This statement demonstrates a misunderstanding of hypertension management. Antihypertensive drugs work best when combined with ongoing lifestyle modifications, including reduced sodium intake, regular exercise, limited alcohol consumption, and stress management. Discontinuing these habits can lead to poor blood pressure control and increased risk of cardiovascular complications despite medication adherence. The nurse should reinforce that lifestyle changes are a lifelong commitment, not a temporary measure.
Rationales for incorrect answers:
B. “I will walk every day at least 20 minutes.”
This reflects positive adherence to exercise recommendations. Regular physical activity, such as brisk walking for 20–30 minutes most days of the week, improves cardiovascular function and helps reduce blood pressure.
C. “I will weigh myself at the same time every day and report a weight gain of more than 2 pounds.”
Daily weight monitoring helps detect fluid retention, especially in clients taking diuretics or those with cardiovascular comorbidities. This is an appropriate and safe self-care behavior.
D. “I think that I can keep track of my blood pressure using a journal to record it.”
Keeping a blood pressure log demonstrates active self-monitoring, which allows both the patient and provider to evaluate treatment effectiveness and make necessary adjustments. This behavior supports effective long-term hypertension management.
Take-home points:
• Lifestyle modifications must continue even after antihypertensive therapy begins.
• Medication and healthy habits work synergistically to maintain optimal blood pressure control.
• Patient education should emphasize that long-term adherence to both pharmacologic and lifestyle measures prevents complications and promotes cardiovascular health.
Whether you are a student looking to ace your exams or a practicing nurse seeking to enhance your expertise , our nursing education contents will empower you with the confidence and competence to make a difference in the lives of patients and become a respected leader in the healthcare field.
Visit Naxlex, invest in your future and unlock endless possibilities with our unparalleled nursing education contents today
Report Wrong Answer on the Current Question
Do you disagree with the answer? If yes, what is your expected answer? Explain.
Kindly be descriptive with the issue you are facing.