Which of the following side effects is associated with the blockade of attachment of norepinephrine to alpha-1 receptors?
Orthostatic hypotension
Increased psychotic symptoms
Severe appetite disturbance
Hypertensive crisis
The Correct Answer is A
Choice A reason: Blocking norepinephrine at alpha-1 receptors inhibits vasoconstriction, reducing vascular tone. This disrupts baroreceptor-mediated blood pressure regulation, causing orthostatic hypotension when standing. The autonomic nervous system fails to compensate for positional changes, leading to dizziness and fainting, a common side effect of alpha-1 blockers like prazosin.
Choice B reason: Increased psychotic symptoms are linked to dopamine dysregulation, not alpha-1 receptor blockade. Norepinephrine blockade affects autonomic functions, not psychosis, which involves mesolimbic dopamine hyperactivity. This side effect is unrelated to alpha-1 receptors, making this option scientifically inaccurate for the described mechanism.
Choice C reason: Appetite disturbance is typically associated with serotonin or histamine receptor effects, not alpha-1 norepinephrine blockade. Norepinephrine at alpha-1 receptors regulates vascular tone, not appetite control, which involves hypothalamic signaling. This side effect is not a direct consequence of alpha-1 blockade, rendering this option incorrect.
Choice D reason: Hypertensive crisis results from excessive norepinephrine activity, often due to monoamine oxidase inhibitors, not alpha-1 receptor blockade. Blocking alpha-1 receptors causes vasodilation, lowering blood pressure, not raising it. This makes hypertensive crisis an unlikely side effect, contrary to the pharmacological mechanism of alpha-1 blockers.
Nursing Test Bank
Naxlex Comprehensive Predictor Exams
Related Questions
Correct Answer is C
Explanation
Choice A reason: Silently adding an inappropriate outcome disregards patient safety and autonomy. Outcomes must align with neurobiological needs, like serotonin modulation for depression. This approach fails to engage the patient in decision-making, risking ineffective treatment and neglecting evidence-based collaborative care principles.
Choice B reason: Formulating outcomes without patient input violates autonomy. Collaborative goal-setting, considering neurobiological factors like dopamine imbalances, ensures patient engagement and effective treatment. Excluding the patient disregards their perspective, reducing adherence and therapeutic alliance, making this approach contrary to evidence-based psychiatric nursing.
Choice C reason: Exploring consequences respects autonomy while guiding patients toward safe outcomes. Discussing implications, like medication non-adherence worsening dopamine-driven symptoms, fosters informed decisions. This collaborative approach aligns with cognitive-behavioral principles and neurobiological treatment needs, ensuring effective, patient-centered care in psychiatric practice.
Choice D reason: Educating that an outcome is unrealistic may dismiss patient autonomy. While addressing neurobiological realities, like serotonin deficits, is important, unilateral education risks disengagement. Collaborative exploration of consequences is more effective, promoting informed choices and adherence, making this option less suitable than discussion.
Correct Answer is C
Explanation
Choice A reason: Socialization and mutual needs define social relationships, not therapeutic ones. Therapeutic relationships focus on patient needs, like addressing serotonin-driven depression, not reciprocal sharing. This approach risks blurring professional boundaries, making it incorrect for psychiatric nursing’s patient-centered focus.
Choice B reason: Mutual growth and satisfaction characterize social partnerships, not therapeutic relationships. In psychiatric care, the focus is on patient recovery, addressing issues like dopamine imbalances, not nurse satisfaction. This option misaligns with the professional, patient-centered nature of therapeutic relationships.
Choice C reason: The therapeutic relationship centers on the patient, addressing issues like amygdala-driven anxiety through collaborative discussion. Solutions, like medication adherence, are patient-driven to promote autonomy, aligning with neurobiological and psychological recovery principles, making this the correct description of the therapeutic dynamic.
Choice D reason: Shifting focus and mutual advice blur professional boundaries, resembling social relationships. Therapeutic relationships prioritize patient needs, like serotonin stabilization, with nurse guidance, not reciprocal advice. This option misrepresents the patient-centered, evidence-based nature of psychiatric therapeutic relationships.
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