What is the difference between innate immunity and adaptive immunity?

The largest organ in the human body by surface area is the skin. It covers the entire external surface of the body and has an average surface area of about 20 square feet in adults.

Down syndrome is a genetic disorder caused by the presence of an extra copy of chromosome 21. It is also known as trisomy 21, because affected individuals have three copies of chromosome 21 instead of the normal two.

The extra chromosome 21 in Down syndrome occurs due to a random error in cell division, which leads to the production of an abnormal gamete (egg or sperm) with an extra copy of the chromosome. When this gamete fuses with a normal gamete during fertilization, the resulting zygote has 47 chromosomes instead of the usual 46, and develops into a fetus with Down syndrome.

Down syndrome is characterized by a range of physical and intellectual symptoms, including developmental delays, intellectual disability, distinctive facial features, heart defects, and increased risk of certain medical conditions such as leukemia and Alzheimer's disease. However, the severity and expression of these symptoms can vary widely among affected individuals.

Spirometry is a common pulmonary function test that measures pulmonary ventilation, specifically assessing the volume and flow of air that can be inhaled and exhaled from the lungs. It provides important information about lung function and can help diagnose various respiratory conditions.

The other options do not relate to spirometry:

• A. Urinary capacity of the bladder: This is measured by urodynamics or bladder capacity tests, not spirometry.
• B. Volume of blood in the body: This can be estimated using different methods, such as dilution techniques or imaging, but not spirometry.
• D. Number of turns in the small intestine: This relates to the anatomy and function of the digestive system and is not measured by spirometry.

Thus, spirometry specifically evaluates how well the lungs are functioning in terms of air movement.

Muscle contraction is a complex process that involves the interaction between actin and myosin filaments in the muscle fibers. The sliding of these filaments is initiated by the release of calcium ions from the sarcoplasmic reticulum, a specialized organelle in muscle cells. The calcium ions bind to the protein troponin, which causes a conformational change in the troponin-tropomyosin complex, exposing the myosin-binding sites on actin. This allows the myosin heads to bind to actin, forming cross-bridges that pull the actin filaments towards the center of the sarcomere, resulting in muscle contraction.

Option a) is incorrect because calcium does not bind to tropomyosin directly, but rather binds to the protein troponin, causing a conformational change in the troponin-tropomyosin complex. Option c) is incorrect because calcium does not activate motor neurons, but rather is released from the sarcoplasmic reticulum in response to an action potential that travels down the motor neuron to the neuromuscular junction. Option d) is incorrect because calcium is required for muscle contraction, not relaxation. The relaxation of muscles after contraction is due to the active transport of calcium ions back into the sarcoplasmic reticulum, which allows the troponin-tropomyosin complex to return to its resting conformation, blocking the myosin-binding sites on actin and ending the cross-bridge cycle.

In the case of methanol poisoning, the metabolism of methanol to formaldehyde is a critical concern because formaldehyde is highly toxic. Ethanol is used as a treatment because it competes with methanol for the same enzyme, methanol oxidase (or alcohol dehydrogenase), effectively inhibiting the metabolism of methanol. By inhibiting the enzyme, ethanol reduces the conversion of methanol to formaldehyde, thereby minimizing its toxic effects.

Here’s why the other options are not suitable treatments:

• A. Methanol oxidase, which would increase the rate of the reaction: This would not be a treatment; it would worsen the situation by promoting the conversion of methanol to toxic formaldehyde.
• B. Methanol, which would saturate the methanol oxidase: This option would also be harmful, as adding more methanol would only lead to more formaldehyde production.
• C. Ice, which would shift the equilibrium of the reaction: The reaction is not a typical equilibrium reaction in this context, and cooling the body does not address the metabolic conversion of methanol to formaldehyde.

Thus, administering ethanol is an effective treatment to prevent the toxic effects of methanol metabolism.

Osmosis is the process by which water molecules move across a selectively permeable membrane from an area of high concentration to an area of low concentration, in order to equalize the concentration of solutes on both sides of the membrane. Selectively permeable membranes allow only certain molecules to pass through, while preventing the passage of others.

In osmosis, the movement of water molecules is driven by the concentration gradient of solutes, which cannot pass through the membrane. If one side of the membrane has a higher concentration of solutes than the other, water molecules will move from the side with the lower concentration of solutes to the side with the higher concentration of solutes, in an atempt to dilute the solutes and equalize the concentration on both sides.

Osmosis is important in many biological processes, including the uptake of water by plant roots, the regulation of water balance in animal cells, and the preservation of food by adding salt or sugar to create a hypertonic environment that inhibits bacterial growth.

A frameshift mutation is a type of genetic mutation that involves the insertion or deletion of one or more nucleotides in a DNA sequence. This can cause a shift in the reading frame of the genetic code, resulting in a change in the amino acid sequence of the resulting protein. Frameshift mutations can have significant effects on the function of the protein and can lead to genetic disorders or diseases.

The scientific purpose of retracing the steps of a fatal expedition, such as the 1924 climb of Mount Everest, would primarily be to assess the factors that contributed to the earlier expedition's failure. By analyzing the conditions, decisions made, and circumstances surrounding the previous climb, the mountaineer can gain insights into potential dangers, challenges, and mistakes that were encountered, which can inform current climbing practices and safety measures.

Here's why the other options are less appropriate as primary scientific purposes:

• B. To measure the oxygen levels at high elevation: While measuring oxygen levels can be a scientific goal, it is not the main focus if the intent is to understand the failure of the previous expedition specifically.
• C. To identify routes that can be explored in future climbs: This could be a minor aspect of the climb, but the emphasis is on understanding the past tragedy rather than route exploration.
• D. To show that modern technology makes climbing safer: Although modern technology may improve safety, the primary purpose of the climb, given the context, would be to learn from historical events rather than to prove a point about technology.

Thus, the scientific purpose of such a climb would be to assess why the earlier expedition failed.

Diaphragm is responsible for regulating breathing rate and depth. It is a dome-shaped muscle located at the

bottom of the chest cavity that contracts and relaxes to help move air in and out of the lungs.

Transfer RNA (tRNA) is a type of RNA molecule that carries amino acids to the ribosome during protein synthesis. Each tRNA molecule has a specific sequence of three nucleotides called an anticodon, which pairs with a complementary codon in the messenger RNA (mRNA) sequence. Each tRNA also carries a specific amino acid that corresponds to the codon it recognizes, allowing the ribosome to link the amino acids together in the correct order to form a protein.

In contrast, messenger RNA (mRNA) carries the genetic information from the DNA to the ribosome, where it serves as a template for protein synthesis. Ribosomal RNA (rRNA) is a component of the ribosome itself, where it helps to catalyze the formation of peptide bonds between amino acids. Small nuclear RNA (snRNA) is involved in splicing of pre-mRNA molecules during post-transcriptional processing.