A 62-year-old woman suffers internal Injuries in an automobile accident and appears to be in a state of shock. Two days later, the patient develops rapidly progressive respiratory distress and a pattern of “’interstitial pneumonia” on chest x-ray (shock lung). Which of the following pathologic findings could be expected in the lungs of this patient with diffuse alveolar carriage?

A 72-year-old man who works for a mine in Libby, Montana, has a clinical history of pulmonary function tests that show a decreased FEV, and FVC, with a normal FEV1/FVC ratio. He dies and an autopsy is performed. The autopsy reveals a tumor in the right pleural cavity, which completely encases the lung. He also has tan- white pleural plaques in the right pleural cavity. Upon histologic examination of the lung, prominent alveolar septal fibrosis with honeycomb change is identified. This patient was most likely exposed to which of the following agents?

A 67-year-old woman with a history of diabetes, systemic hypertension and recent myocardial infarction suddenly develops gangrene of her left toe. The patient's vital signs are unremarkable. Blood cultures are negative. What is the most likely cause of necrosis in this patient?

A 68-year-old male with a history of severe COPD presents to the emergency department with acute onset dyspnea, tachypnea, peripheral edema, and jugular venous distention. He reports worsening fatigue and shortness of breath over several weeks, now occurring at rest. Physical exam reveals cyanosis, a loud P2 heart sound, and hepatomegaly. An echocardiogram demonstrates right ventricular dilation with right ventricular hypertrophy and reduced right ventricular systolic function. Which of the following is the most likely diagnosis?

A 26-year-old woman who recently emigrated from Africa presents with swelling of her right leg (patient with elephantiasis shown). What is the name for fluid accumulation in the soft tissue of this patient's night leg?

A 48-year-old man with a history of heavy smoking presents with a 3-year history of persistent cough and frequent upper respiratory infections, associated with sputum production. Analysis of arterial blood gases reveals hypoxia and CO2 retention. Which of the following is the appropriate diagnosis?

A 65-year-old man from Asia suffers a massive stroke and expires. The lungs are examined at autopsy (image shown). This pulmonary lesion is associated with which of the following infectious diseases?

Varicose veins of the legs, as well as esophageal varices, hemorrhoids and varicocele of the scrotum, are all characterized by which of the following pathologic features?

A 69-year-old man Is brought to be Emergency Department because of the sudden-onset of left-sided chest pain that is exacerbated upon inspiration. Physical examination reveals dyspnea and hemoptysis. His temperature is 38’C (101”F), pulse is 110/min. respirations are 35/min. and blood pressure is 158/100 mm Hg. A lateral chest wall friction rub is present on auscultation. The left leg Is markedly edematous. A chest x-ray reveals a left pleural effusion. What is the most likely cause of this patient” s left-sided chest pain, pleural effusion. dyspnea, and hemoptysis?

A 72-year-old woman complains of shortness of breath on exertion. She states that she also becomes short of breath at night unless she uses three pillows to prop herself up (orthopnea). Physical examination reveals mild obesity, bilateral pitting leg edema, an enlarged liver, and fine crackling sounds on inspiration (rales). A chest x-ray shows cardiomegaly. What is the most likely cause of orthopnea in this patient?

A 32-year-old woman who weighs 125 kg (275 lb) is in the hospital for open reduction and internal fixation of a fractured ankle. She states that the only medication she is taking is an oral contraceptive. Four days after the surgery, she suddenly complains of chest pain and is noted to have difficulty breathing. Pulse oximetry reveals an arterial pO2 of 75%. She becomes unresponsive. During resuscitation, she is noted to have pulseless electrical activity. Despite aggressive efforts, she dies. An autopsy is most likely to reveal which of the following conditions?