A nurse is caring for a patient diagnosed with emphysema.
The patient has a known history of alpha-1 antitrypsin deficiency.
The nurse understands that this genetic condition:
Leads to the destruction of alveolar walls, contributing to emphysema development.
Causes excessive mucus production, leading to chronic bronchitis.
Increases the production of surfactant, helping to prevent alveolar collapse.
Reduces the risk of emphysema by enhancing the immune system response.
The Correct Answer is A
Choice A rationale
Alpha-1 antitrypsin is a protein that protects the lungs from being damaged by inflammation and enzymes like neutrophil elastase. When a deficiency exists, these enzymes are unchecked and begin to break down the elastin in the alveolar walls. This destruction reduces the surface area for gas exchange and causes the permanent enlargement of air spaces characteristic of emphysema. This genetic lack of protection leads to early-onset lung disease even in the absence of heavy smoking.
Choice B rationale
Excessive mucus production and chronic cough are the hallmarks of chronic bronchitis, which involves inflammation of the bronchial tubes rather than the primary destruction of the alveoli. While chronic bronchitis and emphysema both fall under the umbrella of COPD, alpha-1 antitrypsin deficiency specifically targets the structural integrity of the alveolar sacs through enzymatic degradation. It does not primarily drive the goblet cell hyperplasia or the hypersecretion of mucus that defines the clinical presentation of chronic bronchitis.
Choice C rationale
Surfactant is a lipoprotein that reduces surface tension within the alveoli to prevent collapse during expiration. Alpha-1 antitrypsin deficiency does not increase surfactant production; rather, it allows for the destruction of the very tissues that produce and are supported by surfactant. Increased surfactant would generally be a positive physiological adaptation, but in this genetic condition, the pathology is centered on the loss of elastic recoil and tissue destruction due to an imbalance between proteases and antiproteases.
Choice D rationale
Alpha-1 antitrypsin deficiency significantly increases the risk of emphysema rather than reducing it. The condition represents a failure of the body's protective mechanisms against proteolytic enzymes. It does not enhance the immune system; instead, it leaves the lung tissue vulnerable to the normal inflammatory responses of the immune system. Without this inhibitor, even minor respiratory irritations can lead to significant and irreversible lung damage, making the patient much more susceptible to developing severe respiratory failure.
Nursing Test Bank
Naxlex Comprehensive Predictor Exams
Related Questions
Correct Answer is []
Explanation
NGN Bowtie: Asthma Management
|
Actions to Take (2) |
Condition |
Parameters to Monitor (2) |
|
1. Place the client upright in bed |
Asthma |
1. Oxygen saturation |
|
2. Plan to administer a bronchodilator |
2. Respiratory rate |
Rationale
- Condition:The patient's symptoms (dry cough at night, chest tightness, and wheezing) combined with a history of using "as-needed inhalers" are classic indicators of Asthma. While COPD presents similarly, the episodic nature and the description of the cough suggest asthma. Pneumonia and Pulmonary Edema typically present with fever or crackles (rales), respectively, which are absent here.
- Actions to Take:* Place the client upright:This is the immediate non-pharmacological priority to maximize lung expansion and decrease the work of breathing.
- Administer a bronchodilator:This is the definitive medical treatment to reverse the airway constriction (bronchospasm) causing the wheezing.
- Note:Antibiotics are for infections, and a bronchoscopy is an invasive diagnostic tool not indicated for an acute asthma flare.
- Parameters to Monitor:
- Oxygen saturation:Essential to determine if the interventions are improving gas exchange (the current 90% is below the typical target of ≥94%).
- Respiratory rate:A decrease in the rate (currently 28/min) indicates that the patient's respiratory distress is resolving and they are not tiring out.
Correct Answer is D
Explanation
Choice A rationale
While observing for confusion is important, especially in older adults who may experience post-operative delirium or hypoxia, it is not the absolute priority immediately after a bronchoscopy. Confusion can be a sign of many issues, but airway protection must be established first. Assessing the neurological status is part of a comprehensive post-procedural assessment, but it follows the immediate physiological safety checks required to prevent aspiration and ensure the patient is stabilized.
Choice B rationale
Auscultating breath sounds is a necessary part of the post-bronchoscopy assessment to check for complications like a pneumothorax or diminished air entry. However, the immediate risk following the administration of local anesthesia to the throat is the loss of protective airway reflexes. While breath sounds provide information about lung expansion, the ability to protect the airway from gastric contents or saliva takes precedence in the very first moments of the recovery phase to prevent aspiration.
Choice C rationale
Measuring blood pressure is a standard part of monitoring vital signs to ensure hemodynamic stability after any procedure involving sedation. While hypotension or hypertension can occur, it is generally considered a lower priority than airway management. Normal blood pressure is typically 120 over 80 mmHg. Monitoring vitals helps detect internal bleeding or reactions to anesthesia, but the immediate physical obstruction or aspiration risk is the most critical factor to address first.
Choice D rationale
The primary concern after a bronchoscopy is the return of the gag reflex. During the procedure, the pharynx is typically numbed with a local anesthetic to prevent coughing and gagging. Until this reflex returns, the patient is at a high risk for aspiration. The nurse must keep the patient NPO (nothing by mouth) and confirm the gag reflex is intact before allowing any oral intake. Ensuring airway protection is always the highest priority in the nursing process.
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