A nurse is preparing to administer the initial dose of penicillin G IM to a client. The nurse should monitor for which of the following as an indication of an allergic reaction following the injection?

A. Methimazole can lead to weight gain rather than weight loss.

B. Methimazole can cause hypersomnolence.

C. Methimazole does not typically affect skin temperature.

D. Methimazole is an antithyroid medication used to treat hyperthyroidism, including Graves' disease and can cause a decrease in heart rate.

A. The client's liver function test results are within the expected reference range: While monitoring liver function tests is essential for clients taking isoniazid and rifampin due to
potential hepatotoxicity, normal liver function test results do not necessarily indicate adherence to the medication regimen. Adherence is best assessed by the client's response to treatment, such as improvement in symptoms and resolution of the infection.
B. The client has a positive purified protein derivative test: A positive purified protein derivative (PPD) test indicates exposure to Mycobacterium tuberculosis but does not provide information about the client's adherence to the medication regimen for tuberculosis treatment. Adherence to treatment is determined by factors such as medication compliance and therapeutic response.
C. The client tests negative for HIV: The client's HIV status is not directly related to adherence to the tuberculosis medication regimen. While co-infection with HIV can impact the management of tuberculosis, testing negative for HIV does not confirm adherence to tuberculosis treatment.
D. The client has a negative sputum culture: A negative sputum culture indicates the absence of viable Mycobacterium tuberculosis organisms in the sputum sample and suggests effective
treatment and adherence to the medication regimen. Monitoring sputum culture conversion is a key indicator of treatment success in tuberculosis therapy.