A nurse is to administer Dobutamine (Dobutrex) 2.5 mcg/kg/min IV to a patient with severe heart failure who weighs 130 pounds. The pharmacy prepares a solution of 250 mg of Dobutrex in 500 mL D5W. How many mL of the medication should be administered to the patient per hour? Round your answer to the nearest whole number.

Systemic vascular resistance represents the resistance to blood flow in the systemic circulation. It is an important indicator of afterload, which is the force against which the left ventricle must pump to eject blood into the systemic circulation. By monitoring the changes in SVR, the nurse can assess the impact of medications aimed at reducing left ventricular afterload.
A. Pulmonary artery wedge pressure (PAWP) in (option A) is incorrect because: PAWP is a measure of left ventricular preload and reflects the pressure within the left atrium and left ventricle at end-diastole. It is not specifically related to afterload reduction.
C. Pulmonary vascular resistance (PVR) in (option C) is incorrect because: PVR represents the resistance to blood flow in the pulmonary circulation. It is not directly related to left ventricular afterload.
D. Central venous pressure (CVP) in (option D) is incorrect because: CVP reflects the pressure in the right atrium and is an indicator of right-sided cardiac function. It is not specifically related to left ventricular afterload reduction.
Therefore, to assess the effectiveness of medications in reducing left ventricular afterload, the nurse should monitor the systemic vascular resistance (SVR).

Central venous pressure (CVP) is a measurement of the pressure in the central veins, which reflects the blood volume and right-sided cardiac function. High CVP readings may indicate fluid overload or impaired cardiac function, and intervention is necessary to address the underlying cause.
Administering IV diuretic medications can help reduce fluid volume by increasing urine output and promoting fluid elimination. By removing excess fluid, the diuretic medications can help lower the CVP and alleviate the high pressures.
The other options mentioned are not the anticipated actions for addressing high CVP:
A. Increasing the IV fluid infusion rate in (option A) is incorrect because: If the CVP is already indicating high pressures, increasing the IV fluid infusion rate would further contribute to fluid overload and exacerbate the problem. This action would not be appropriate for high CVP readings.
C. Elevating the head of the patient's bed to 45 degrees in (option C) is incorrect because Positioning the patient with the head of the bed elevated is commonly done to prevent complications such as aspiration or improve respiratory function. While it may have other benefits, it does not directly address the high CVP.
D. Documenting the CVP and continuing to monitor in (option D) is incorrect because Documenting the CVP and continuing to monitor is important for ongoing assessment and evaluation. However, in the presence of high CVP readings, intervention is necessary to address the underlying issue rather than solely documenting and monitoring.
Therefore, when a patient's CVP monitor indicates high pressures following surgery, the nurse would anticipate administering IV diuretic medications to help reduce fluid volume and lower the CVP.