A patient is taking an antacid concurrently with ketoconazole.

The antacid inhibits the dissolution of ketoconazole.

Which term accurately describes this result?.

Choice A rationale:
While distribution can affect a person’s response to medication, it is not the aspect of genetic makeup most likely to alter this response.
Choice B rationale:
Absorption can affect how a drug is taken up by the body, but it is not the aspect of genetic makeup most likely to alter a person’s response to medication.
Choice C rationale:
Excretion, or how the body eliminates a drug, can affect drug response, but it is not the aspect of genetic makeup most likely to alter this response.
Choice D rationale:
Metabolism, or how the body processes a drug, is the aspect of genetic makeup most likely to alter a person’s response to medication. Genetic differences can lead to variations in drug-metabolizing enzymes, affecting how quickly or slowly drugs are metabolized.

Choice A rationale:
A decrease in blood pressure is a common side effect when a medication increases urine output, as the reduction in fluid volume can lead to lower blood pressure.
Choice B rationale:
While a decrease in blood pressure might be desired in certain conditions (like hypertension), in this context it is a side effect, not the primary desired effect.
Choice C rationale:
The therapeutic effect of the medication in this case is to increase urine output, not to decrease blood pressure.