Arformoterol belongs to which of the following therapeutic drug class(es)?
COPD Agent
Antitussive
Antihistamine
Bronchodilator
Correct Answer : A,D
A. Arformoterol is indicated for the long-term maintenance treatment of bronchoconstriction in patients with chronic obstructive pulmonary disease. It acts as a long-acting beta-2 adrenergic agonist to improve forced expiratory volume. This clinical application defines its classification.
B. This drug lacks activity on the cough reflex center in the medulla oblongata. It does not possess the pharmacological properties of peripheral or central antitussives like codeine or dextromethorphan. It is not used to suppress non-productive cough.
C. Arformoterol does not antagonize H1 receptors or inhibit the release of histamine from mast cells. Its mechanism of action is independent of the inflammatory pathways targeted by antihistamines. It serves no role in treating allergic rhinitis or urticaria.
D. As the (R,R)-enantiomer of formoterol, it stimulates adenylate cyclase to increase intracellular cyclic adenosine monophosphate levels. This process leads to the relaxation of bronchial smooth muscle cells. The resulting increase in airway caliber defines it as a bronchodilator.
Nursing Test Bank
Naxlex Comprehensive Predictor Exams
Related Questions
Correct Answer is C
Explanation
A. Focalin is the brand name for dexmethylphenidate, which is the d-threo-enantiomer of methylphenidate. It acts primarily as a dopamine and norepinephrine reuptake inhibitor. It does not contain the sulfate or saccharate salts of the amphetamine molecule found in the question.
B. Vyvanse contains lisdexamfetamine dimesylate, a prodrug converted to dextroamphetamine in the blood. While it provides dextroamphetamine, it is a single-molecule formulation rather than a mixture of salts. It lacks the levoamphetamine component found in the mixed salt combination.
C. Adderall is the proprietary name for a combination of 4 different amphetamine salts. It specifically consists of dextroamphetamine saccharate, dextroamphetamine sulfate, amphetamine aspartate monohydrate, and amphetamine sulfate. This mixture provides a specific ratio of 3 to 1 dextroamphetamine to levoamphetamine.
D. Ritalin is the brand name for methylphenidate hydrochloride, a central nervous system stimulant. Its mechanism involves the inhibition of the dopamine transporter and norepinephrine transporter. It is chemically distinct from the phenethylamine derivatives found in amphetamine and dextroamphetamine salt mixtures.
Correct Answer is B
Explanation
A. Albuterol sulfate is a short-acting beta-2 agonist while tiotropium bromide is a long-acting muscarinic antagonist. This specific combination is not marketed under the brand Advair. It is typically used for separate bronchodilatory pathways in chronic obstructive pulmonary disease.
B. Advair is the brand name for the combination of fluticasone propionate and salmeterol xinafoate. Fluticasone is a potent corticosteroid that reduces airway inflammation. Salmeterol is a long-acting beta-2 adrenergic agonist that maintains bronchodilation through cyclic adenosine monophosphate.
C. Budesonide and formoterol fumarate dihydrate represent the generic components of the brand Symbicort. While it contains a corticosteroid and a long-acting beta-2 agonist, it is a different molecular entity. It is not the generic name for Advair.
D. Albuterol sulfate and ipratropium bromide are the active ingredients in the brand Combivent or DuoNeb. This mixture combines a short-acting beta-2 agonist with a short-acting muscarinic antagonist. It is not associated with the proprietary name Advair.
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