Cefazolin sodium 250 mg IV every 8 hours is ordered for your patient. You are to reconstitute with 2.5 ml sterile normal saline. After reconstitution the vial contains 225 mg/ml. How many ml will you administer per dose?
3.3 ml
1.1 ml
2.5 ml
1 ml
The Correct Answer is B
Rationale:
A. 3.3 mL would deliver approximately 742 mg, which is far above the prescribed dose.
B. 1.1 mL provides approximately 250 mg, matching the provider’s order.
First, identify the ordered dose and the available concentration.
Ordered dose = 250 mg
Available concentration = 225 mg per 1 mL
Use the medication calculation formula:
Amount to administer (mL) = Ordered dose ÷ Concentration
250 mg ÷ 225 mg/mL = 1.11 mL, which rounds to 1.1 mL
C. 2.5 mL refers to the reconstitution volume, not the amount to administer.
D. 1 mL would deliver only 225 mg, which is less than the prescribed dos
Nursing Test Bank
Naxlex Comprehensive Predictor Exams
Related Questions
Correct Answer is D
Explanation
Rationale:
A. Dextrose 5% in water (D5W) is a hypotonic solution that primarily provides free water for hydration. It is not appropriate for initial burn resuscitation because it does not replace the large volume of electrolytes lost from the intravascular space due to fluid shifts and third-spacing.
B. Dextrose 5% in 0.9% sodium chloride (D5NS) contains both glucose and sodium but is not typically used in the first 24 hours of burn resuscitation. The glucose component is unnecessary initially, and isotonic replacement with electrolytes is preferred.
C. 0.9% sodium chloride (normal saline) is an isotonic solution and can be used for volume expansion. However, it does not contain the electrolytes (like lactate) that help buffer metabolic acidosis, which is common after extensive burns.
D. Lactated Ringer's (LR) is the preferred fluid for the first 24 hours after a burn injury. LR is isotonic, contains electrolytes similar to plasma (sodium, potassium, calcium, and chloride), and includes lactate, which is metabolized to bicarbonate and helps counteract metabolic acidosis from tissue hypoperfusion. It is used with formulas like the Parkland formula to calculate precise fluid replacement volumes.
Correct Answer is ["6.7"]
Explanation
Step 1: Identify the ordered dose.
Ordered dose = 67 mg
Step 2: Identify the available concentration.
40 mg in 4 mL = 10 mg per 1 mL
Step 3: Use the formula.
mL to administer = Ordered dose ÷ Concentration
67 mg ÷ 10 mg/mL = 6.7 mL
Answer: 6.7 mL
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