The basic pathology in Pediatric Autoimmune Neuropsychiatric Disorders associated with Streptococcus (PANDAS) causing OCD in children is development of antibodies against:
Basal ganglia
Hippocampus
Cingulate cortex
Mammillary bodies
The Correct Answer is A
Pediatric Autoimmune Neuropsychiatric Disorders associated with Streptococcus (PANDAS) is a condition where autoantibodies target neuronal tissue following a Group A Streptococcal infection. These antibodies cross-react with brain structures, particularly the basal ganglia, leading to abrupt onset of obsessive-compulsive behaviors and motor tics. The basal ganglia regulate motor control, behavior, and emotion, making them central to the neuropsychiatric symptoms seen in PANDAS. The pathophysiology involves molecular mimicry, where streptococcal antigens resemble neuronal proteins, triggering an autoimmune response.
Rationale for correct answers
1. The basal ganglia are the primary target of autoantibodies in PANDAS, leading to dysfunction in motor and behavioral regulation. This explains the sudden onset of OCD and tics.
Rationale for incorrect answers
2. The hippocampus is involved in memory and spatial navigation, not typically affected in PANDAS. Autoantibody targeting here would not explain OCD or motor tics.
3. The cingulate cortex modulates emotion and decision-making, but it is not the primary site of autoimmune attack in PANDAS. Its involvement is secondary, if at all.
4. The mammillary bodies are linked to memory consolidation and are not implicated in the autoimmune pathology of PANDAS. Their dysfunction does not produce OCD-like symptoms.
Take Home Points
- PANDAS is triggered by Group A Streptococcal infection leading to autoimmune attack on basal ganglia.
- Symptoms include abrupt onset of OCD, motor tics, and emotional dysregulation.
- Differentiation from Tourette syndrome and Sydenham chorea is essential due to overlapping features.
- Treatment may involve antibiotics, immunomodulatory therapy, and psychiatric support.
Nursing Test Bank
Naxlex Comprehensive Predictor Exams
Related Questions
Correct Answer is ["A","B","C","E"]
Explanation
Obsessive-compulsive disorderis a chronic anxiety disorder characterized by persistent, intrusive obsessions and repetitive compulsions intended to reduce distress. It is associated with dysregulation in cortico-striato-thalamo-cortical circuits, often beginning in adolescence. Treatment involves exposureand response prevention therapy alongside pharmacologic interventions such as SSRIs. Symptom management requires a structured, collaborative care plan, respecting safety and physiologicalneeds while gradually reducing maladaptive behaviors.
Rationale for correct answers
1.Evaluating prior copingstrategies helps identify ineffective behaviors and informs tailored interventions to reduce anxiety without reinforcing compulsions.
2.Allowing completion of rituals initially prevents panicescalation, creating trust before initiating gradual exposure and response prevention.
3.Collaborative limit setting fosters autonomyand reduces defensiveness, allowing gradual modification of compulsions without overwhelming the client.
5.Exploring feelings around symptoms builds insightinto triggers and maintains therapeutic alliance, aiding motivation for behavioral change.
Rationale for incorrect answers
4.Directly confronting the impact of compulsions early can increase defensiveness, heighten anxiety, and hinder rapport before trust is established.
Take Home Points
- OCD involves obsessions and compulsions maintained by anxiety-reduction reinforcement.
- Initial care should respect rituals to build trust before gradual exposure therapy.
- Collaborative limit setting and emotional exploration enhance adherence to treatment.
- Early confrontation of impairments may harm rapport; timing is critical in psychiatric nursing care.
Correct Answer is D
Explanation
Obsessive-compulsive disorderis a chronic mental health condition involving intrusive thoughts(obsessions) and repetitive acts (compulsions) performed to reduce anxiety. Symptoms often intensify under stress, and compulsions can significantly impair social and occupational functioning. Management focuses on anxiety reduction, gradual exposure, and response preventionwhile maintaining therapeutic rapport. Interventions require a balance between respecting the patient’s coping mechanisms and promoting healthy behavior change.
Rationale for correct answers
4.Supporting rituals initially allows the patient to maintain a sense of control, which reduces acute anxiety, while setting realistic limits prevents the compulsion from dominating daily functioning. This balance fosters trust during the working phase, making gradual modification more acceptable.
Rationale for incorrect answers
1.Restricting movements can abruptly remove a coping mechanism, triggering heightened distressand potentially causing the patient to withdraw from therapeutic engagement.
2.Calling attention to the behavior in a critical manner can increase shame, leading to resistance and decreased openness in the therapeutic relationship.
3.Simply keeping the patient busy may provide temporary distraction, but it fails to address the underlying anxiety and the compulsive drive sustaining the behavior.
Take Home Points
- OCD involves obsessions and compulsions that temporarily relieve anxiety but reinforce the cycle of symptoms.
- Supportive limits help reduce compulsions without causing defensive withdrawal.
- Abrupt restriction of rituals can worsen anxiety and damage trust.
- Effective management combines therapeutic rapport with gradual exposure and response prevention.
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