The nurse cares for the client with a history of pulmonary tuberculosis (TB). Two granulomas were present in the chest x-ray. Which explanation does the nurse understand best describes the primary immune response to tuberculosis infection?

Infected macrophages and lymphocytes surround the Mycobacterium tuberculosis bacteria and form a tuberculous granuloma.

Tumor necrosis factor is released by T lymphocytes and lyses the Mycobacterium tuberculosis bacteria in the alveoli.

Natural killer cells and neutrophils form a thick purulent debris, which becomes a caseous necrosis.

The inflammatory response of cytokines activates the complement system and causes permanent lung tissue damage.

Answer and Explanation

The Correct Answer is A

Choice A reason: Infected macrophages and lymphocytes surround the Mycobacterium tuberculosis bacteria and form a tuberculous granuloma is the best explanation for the primary immune response to tuberculosis infection. A granuloma is a collection of immune cells that wall off the bacteria and prevent their spread. It is a protective mechanism that limits the infection and preserves the lung function.

Choice B reason: Tumor necrosis factor is released by T lymphocytes and lyses the Mycobacterium tuberculosis bacteria in the alveoli is not a correct explanation for the primary immune response to tuberculosis infection. Tumor necrosis factor is a cytokine that activates macrophages and induces inflammation, but it does not directly kill the bacteria. It may also have harmful effects by causing tissue damage and weight loss.

Choice C reason: Natural killer cells and neutrophils form a thick purulent debris, which becomes a caseous necrosis is not a correct explanation for the primary immune response to tuberculosis infection. Natural killer cells and neutrophils are part of the innate immune system, which is not very effective against intracellular bacteria like Mycobacterium tuberculosis. Caseous necrosis is a type of tissue death that results from the liquefaction of the granuloma. It is a sign of progressive disease, not primary infection.

Choice D reason: The inflammatory response of cytokines activates the complement system and causes permanent lung tissue damage is not a correct explanation for the primary immune response to tuberculosis infection. The inflammatory response of cytokines and the complement system are part of the innate immune system, which is not very effective against intracellular bacteria like Mycobacterium tuberculosis. Permanent lung tissue damage is a complication of chronic or reactivated tuberculosis, not primary infection.

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Correct Answer is B

Explanation

Choice A reason: Liver failure is not the most common cause of this type of pain because it is a condition where the liver loses its ability to perform its vital functions, such as detoxifying the blood, producing bile, and metabolizing nutrients. Liver failure can cause symptoms such as jaundice, ascites, or bleeding, but it does not usually cause burning pain in the feet.

Choice B reason: Diabetes mellitus is the most common cause of this type of pain because it is a condition where the blood glucose level is too high, either due to insufficient insulin production or reduced insulin sensitivity. Diabetes mellitus can cause damage to the nerves, especially in the peripheral areas, such as the feet, which is called diabetic neuropathy. Diabetic neuropathy can cause symptoms such as burning pain, numbness, or tingling in the feet, which can worsen at night or with pressure.

Choice C reason: Mercury toxicity is not the most common cause of this type of pain because it is a condition where the body is exposed to high levels of mercury, which is a toxic metal that can be found in some fish, dental fillings, or thermometers. Mercury toxicity can cause damage to the nervous system, causing symptoms such as tremors, memory loss, or mood changes, but it does not usually cause burning pain in the feet.

Choice D reason: Vitamin B12 deficiency is not the most common cause of this type of pain because it is a condition where the body does not have enough vitamin B12, which is a nutrient that is essential for the production of red blood cells and the maintenance of the nervous system. Vitamin B12 deficiency can cause symptoms such as anemia, fatigue, or weakness, but it does not usually cause burning pain in the feet.

A. Thrombosis of the small blood vessels in the substantia nigra. B. Increased acetylcholine levels and cholinergic activity in the brain. C. Cell-mediated immune response and muscle fiber damage. D. Increased production of dopamine in the motor cortex.

Correct Answer is A

Explanation

Choice A:
Thrombosis of the small blood vessels in the substantia nigra is the best explanation for the clinical manifestations observed in the patient. The substantia nigra is an area in the brain responsible for producing dopamine, a neurotransmitter involved in motor control. Thrombosis, or the formation of blood clots, in the small blood vessels of the substantia nigra can lead to a decrease in dopamine production, resulting in the symptoms of Parkinson's disease.

Choice B:
Increased acetylcholine levels and cholinergic activity in the brain are not the primary factors causing the manifestations of Parkinson's disease. In fact, Parkinson's disease is characterized by a decrease in dopamine levels, not an increase in acetylcholine.

Choice C:
Cell-mediated immune response and muscle fiber damage are not the main mechanisms underlying the clinical manifestations of Parkinson's disease. While inflammation and immune responses may play a role in the progression of the disease, they are not the primary cause of the symptoms observed.

Choice D:
Increased production of dopamine in the motor cortex is not the cause of the symptoms in Parkinson's disease. In fact, patients with Parkinson's disease experience a decrease in dopamine production due to the degeneration of dopamine-producing neurons in the substantia nigra.

Overall, the most plausible explanation for the patient's clinical manifestations is thrombosis of the small blood vessels in the substantia nigra, leading to a decrease in dopamine production.

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The nurse cares for the client with a history of pulmonary tuberculosis (TB). Two granulomas were present in the chest x-ray. Which explanation does the nurse understand best describes the primary immune response to tuberculosis infection?

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Naxlex Comprehensive Predictor Exams

The nurse provides care for a client who reports burning pain, which is worse at night, in both feet. The client states the pressure of the sheets on the feet is "unbearable". Which reason is the most common cause of this type of pain?

Correct Answer is B

Explanation

The nurse provides care for a patient with an 8-year history of Parkinson's disease. The patient has difficulty getting out of chairs, makes tremulous movements, and mumbles words. What is the best explanation for these clinical manifestations?

Correct Answer is A

Explanation

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