The nurse should recognize which of the following signs as a manifestation of sepsis in the neonate? Select all that apply.

Choice A rationale

Antiemetics are most effectively used by administering them proactively, before the chemotherapy agent is started, which is known as prophylactic use. This method allows the medication to achieve therapeutic serum levels and occupy receptors before the emetogenic chemicals stimulate the vomiting center in the brain, thus blocking the nausea pathway.

Choice B rationale

Waiting for nonpharmacologic methods to fail before using antiemetics is ineffective management. Chemotherapy-induced nausea and vomiting are best controlled with aggressive, scheduled pharmacologic intervention from the start, as it is far harder to stop vomiting once the emetic cycle has been established.

Choice C rationale

Starting antiemetics only when nausea begins is reactive and allows the patient to experience unnecessary distress and potential nutritional compromise. The goal in chemotherapy management is prevention; therefore, antiemetics must be started before the patient's exposure to the emetogenic stimuli.

Choice D rationale

Providing antiemetics as needed, or PRN, is a less effective strategy for chemotherapy-induced nausea and vomiting. The intensity of this type of emesis necessitates a scheduled regimen to consistently maintain therapeutic drug levels and prevent the overwhelming onset of nausea and vomiting, which can be difficult to manage once it starts.

Choice A rationale

Inserting a padded tongue blade or any object into the mouth during a seizure is strictly contraindicated as it can cause injury, such as chipping teeth, lacerating gums, or triggering severe jaw clenching, potentially causing airway obstruction or aspiration, which outweighs the risk of the child biting their tongue.

Choice B rationale

Positioning a child in a sitting position during a generalized seizure is dangerous because it provides no support and increases the risk of head injury and aspiration. The child should instead be placed on the floor in a side-lying position, known as the recovery position, to facilitate drainage of oral secretions and maintain a patent airway.

Choice C rationale

Initiating rescue breathing is inappropriate as soon as seizure activity begins, because the child is often breathing but may have irregular or shallow respirations. Interventions should focus on safety and maintaining a patent airway by positioning. Rescue breathing is only indicated if the child stops breathing after the seizure, not during the ictal phase.

Choice D rationale

Moving objects out of the way is the most important immediate safety measure during a tonic-clonic seizure. This action protects the child from striking hard, sharp, or hot objects in the immediate vicinity during uncontrolled, involuntary movements, preventing trauma such as head injury or fracture.