The pathophysiology of attention deficit-hyperactivity disorder (ADHD) includes neurobiological deficits. Which of the following has been suggested as a pathologic basis for ADHD?
Decreased dopamine in the mesocortical pathway and increased dopamine in the mesolimbic pathway
Abnormalities of frontosubcortical pathways
Increased activity in the ventral tegmental area and the nucleus accumbens
Increased serotonin production in the raphe nucleus
The Correct Answer is B
Choice A reason: Alterations in dopamine pathways are involved in ADHD, but the pattern described—decreased dopamine in the mesocortical and increased in the mesolimbic—is more characteristic of schizophrenia rather than ADHD. ADHD involves overall dysregulation and reduced activity in dopaminergic circuits that modulate attention and impulse control.
Choice B reason: Abnormalities of frontosubcortical pathways represent the most consistent neurobiological finding in ADHD. The frontosubcortical circuits connect the prefrontal cortex with subcortical structures like the striatum and thalamus. Dysfunction in these regions leads to deficits in executive function, attention regulation, impulse control, and working memory. Neuroimaging studies show reduced activity and smaller volumes in these regions among individuals with ADHD, correlating with the behavioral symptoms of inattention and hyperactivity.
Choice C reason: Increased activity in the ventral tegmental area and nucleus accumbens would lead to heightened reward-seeking behavior rather than impaired attention. These regions are part of the brain’s reward system, and their increased activity is associated more with addictive behaviors and mania than ADHD.
Choice D reason: Serotonin abnormalities can influence mood and anxiety but are not primary in ADHD’s pathophysiology. ADHD primarily involves dysregulation of dopaminergic and noradrenergic transmission in frontostriatal circuits.
Nursing Test Bank
Naxlex Comprehensive Predictor Exams
Related Questions
Correct Answer is A
Explanation
Choice A reason: A shrill, high-pitched cry in a newborn can indicate serious underlying conditions, including neurological disorders, increased intracranial pressure, or metabolic issues. Prompt evaluation at an emergency department is necessary to rule out life-threatening conditions.
Choice B reason: Changing the baby’s diaper addresses routine discomfort but will not resolve the concern of a high-pitched cry that may indicate serious medical issues. It is insufficient as a primary intervention.
Choice C reason: Feeding the baby may alleviate mild distress due to hunger, but a persistent shrill cry that is unusual warrants immediate medical evaluation.
Choice D reason: Assuming this is normal is unsafe, as abnormal neonatal cries can be the first sign of serious medical conditions. Inaction could delay potentially critical treatment.
Correct Answer is B
Explanation
Choice A reason: Discontinuing an antidepressant after only two weeks with minimal improvement is premature; SSRIs often require 4–6 weeks for full efficacy.
Choice B reason: Making no changes is appropriate at this stage, as early treatment response is modest. The clinician should continue monitoring and reassess after sufficient treatment duration.
Choice C reason: Adding an augmenting agent is not indicated yet, given the patient has only had two weeks of therapy and lacks significant side effects.
Choice D reason: Switching antidepressants is premature at this early stage of treatment; efficacy assessment requires adequate duration.
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