The practical nurse (PN) is preparing cefazolin 400 mg IM for a client with a gram-positive infection. The available vial is labeled, "Cefazolin 1 gram," and the instructions for reconstitution state, for IM use, add 2 mL sterile water for injection. The total volume after reconstitution is 2.5 mL.
After reconstitution, how many mL should be administered to the client?
(Enter numeric value only. If rounding is required, round to the whole number, nearest tenths/hundredth).
The Correct Answer is ["1"]
The concentration of cefazolin after reconstitution can be calculated as follows: Concentration = Total amount of drug / Total volume after reconstitution
Since the available vial contains 1 gram (1000 mg) of cefazolin and the total volume after reconstitution is 2.5 mL, we can calculate the concentration:
Concentration = 1000 mg / 2.5 mL = 400 mg/mL
Therefore, after reconstitution, the concentration of cefazolin is 400 mg/mL.
To administer a dose of 400 mg, we divide the desired dose by the concentration: Volume to administer = Desired dose / Concentration
Volume to administer = 400 mg / 400 mg/mL = 1 mL
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