The provider orders a continuous heparin infusion to begin at 18 units/kg/hr. The patient weighs 73.4kg. The pharmacy supplies heparin in a premixed bag of 25,000 units in 500mL of 5% dextrose solution. Calculate the mL/hr of the pump. Round to the whole number for the pump.

A. Selective estrogen receptor modulators: These agents, such as raloxifene, mimic estrogen’s beneficial effects on bone density while avoiding many of the cardiovascular and breast risks associated with hormone therapy. They are generally safer for postmenopausal women with cardiac concerns.

B. Lipid-lowering agents: These medications, including statins, help reduce cholesterol levels and lower cardiovascular risk. They are appropriate for a client with a history of cardiac problems and can support overall heart health.

C. Long-term hormone replacement therapy: Hormone replacement therapy (HRT) is contraindicated in women with a history of cardiac disease because it increases the risk of myocardial infarction, stroke, and thromboembolic events. The cardiovascular risks outweigh the benefits, particularly in inactive women or those with preexisting heart conditions.

D. Bisphosphonates: Bisphosphonates are used to prevent and treat osteoporosis by inhibiting bone resorption. They are safe and effective for postmenopausal women, including those with cardiac disease, and pose no cardiovascular risk.

A. Initiate chelation therapy with deferoxamine: Deferoxamine is used to treat iron toxicity, not salicylate poisoning. It binds excess iron for renal excretion, so it has no therapeutic effect in cases of acetylsalicylic acid (aspirin) overdose.

B. Perform gastric lavage with activated charcoal: Activated charcoal binds salicylates in the gastrointestinal tract, preventing further absorption into the bloodstream. Gastric lavage followed by charcoal administration is effective when performed soon after ingestion, helping reduce systemic toxicity.

C. Administer N-acetylcysteine: N-acetylcysteine is the antidote for acetaminophen (paracetamol) toxicity. It replenishes hepatic glutathione and protects the liver, but it has no role in neutralizing salicylate poisoning.

D. Induce vomiting with syrup of ipecac: Inducing vomiting is no longer recommended because it can cause aspiration and delay more effective treatments like activated charcoal or gastric lavage. Controlled decontamination under medical supervision is the safer approach.