What statement best describes the pathophysiology of psoriasis?
Psoriasis involves destruction of melanocytes
Psoriasis involves bacterial overgrowth
Psoriasis involves hypersensitivity to allergens
Psoriasis involves excessive epidermal shading
The Correct Answer is D
Rationale:
A. Destruction of melanocytes occurs in conditions such as vitiligo, where the pigment-producing cells are lost, leading to depigmented patches. Psoriasis does not primarily affect melanocytes or pigmentation.
B. While secondary bacterial infections can occur in psoriatic lesions due to skin barrier disruption, bacterial overgrowth is not the underlying cause or pathophysiology of psoriasis.
C. Allergic reactions, such as contact dermatitis, involve hypersensitivity mechanisms, but psoriasis is not triggered by allergens in this manner.
D. Psoriasis is a chronic autoimmune-mediated inflammatory condition in which T-cell activation leads to increased cytokine production, resulting in hyperproliferation of keratinocytes. This accelerates the normal skin cell turnover from about 28–30 days to as little as 3–7 days, causing excessive epidermal shedding, thickened plaques, and silvery scales. The accelerated turnover and abnormal differentiation of epidermal cells are hallmarks of psoriasis pathophysiology, making this the most accurate description.
Nursing Test Bank
Naxlex Comprehensive Predictor Exams
Related Questions
Correct Answer is A
Explanation
Rationale:
A. Decreased range of motion in the affected limb is correct. Contractures are permanent shortening of muscles, tendons, or ligaments that often develop after burn injuries, particularly when deep partial-thickness or full-thickness burns heal with significant scar tissue formation. As scar tissue forms and contracts, it limits joint mobility, leading to restricted range of motion, functional impairment, and deformity. Early recognition and intervention, such as physical therapy, splinting, and proper positioning, are essential to prevent or minimize contractures.
B. Increased muscle strength in the affected limb is incorrect. Contractures result in limited movement and stiffness, not enhanced muscle strength. An increase in strength would suggest recovery and rehabilitation rather than a complication of scarring.
C. Improved flexibility and joint movement is incorrect. Contractures reduce flexibility and impede joint movement. Improved flexibility would indicate successful healing and rehabilitation, not the development of a contracture.
D. Swelling and redness around the burn area is incorrect. While swelling and erythema may occur during the acute inflammatory phase of burn healing, they do not specifically indicate contracture formation. Contractures develop over time as scar tissue matures and tightens, rather than during initial inflammation.
Correct Answer is ["A","B","C"]
Explanation
Rationale:
A. Anemia results in reduced oxygen-carrying capacity of the blood due to low red blood cell or hemoglobin levels. This can cause cerebral hypoxia, leading to dizziness, lightheadedness, or even fainting.
B. Fatigue is a hallmark symptom of anemia because tissues receive less oxygen, impairing cellular metabolism and energy production. Clients often report generalized weakness and decreased exercise tolerance.
C. To compensate for decreased oxygen delivery, the body increases respiratory rate, resulting in dyspnea or shortness of breath, particularly during exertion.
D. Anemia typically causes tachycardia as the cardiovascular system attempts to maintain oxygen delivery to tissues. A decreased heart rate is not a typical sign of anemia.
E. Anemia generally leads to pallor, especially of the skin, mucous membranes, and nail beds, rather than redness (erythema). Pallor occurs due to reduced hemoglobin and decreased perfusion.
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