Which of the following are clinical manifestations of anaphylaxis? select all that apply
Hypertension
Angioedema
Petechiae
Bronchospasm
Correct Answer : B,D
A. Hypertension: Anaphylaxis often leads to a rapid drop in blood pressure (hypotension) rather than hypertension. Hypotension is a more common symptom because of the severe vasodilation that occurs during anaphylactic reactions.
B. Angioedema: Yes, angioedema is a common clinical manifestation of anaphylaxis. Angioedema involves swelling of the deeper layers of the skin, often around the eyes and lips. It can also affect the throat, which can be life-threatening due to airway obstruction.
C. Petechiae: Petechiae are small red or purple spots that appear on the skin and are caused by bleeding into the skin's tissues. They are not a typical manifestation of anaphylaxis.
D. Bronchospasm: Yes, bronchospasm is a hallmark clinical manifestation of anaphylaxis. It involves the sudden constriction of the airways, leading to difficulty in breathing and wheezing.
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Correct Answer is B
Explanation
A. Seizures: Some antibiotics, especially cephalosporins, can lower the seizure threshold, increasing the risk of seizures, especially in individuals prone to seizures or those with a history of epilepsy.
B. Nephrotoxicity: Both cephalosporins and aminoglycosides have the potential to harm the kidneys. When used together, their nephrotoxic effects can be additive, increasing the risk of kidney problems in patients.
C. Hearing Loss: Aminoglycosides, a class of antibiotics that includes drugs like gentamicin, are well-known for their potential to cause hearing loss, especially when used in high doses or for prolonged periods. This effect is due to their toxic impact on the hair cells in the inner ear.
D. Hepatotoxicity: Hepatotoxicity refers to liver damage caused by medications. Some antibiotics, including certain cephalosporins, can have hepatotoxic effects, potentially harming the liver. Monitoring liver function is important when these drugs are used.
Correct Answer is C
Explanation
A. 8:00 AM: This time is too early to draw a trough level for a medication administered at 10:00 AM. The trough level should be drawn just before the next dose is given to get the lowest concentration in the bloodstream.
B. 11:00 AM: This time is after the scheduled dose of vancomycin at 10:00 AM. Waiting until 11:00 AM would not provide an accurate trough level because the patient has already received the medication.
C. 9:00 AM: This is the correct time to obtain the patient's blood sample. It is one hour before the scheduled dose of vancomycin at 10:00 AM. Drawing the trough level at this time ensures it reflects the lowest concentration of the drug in the bloodstream.
D. 12:00 noon: This time is after the scheduled dose of vancomycin at 10:00 AM. Waiting until noon would not provide an accurate trough level because the patient has already received the medication.
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