A kidney transplant recipient stops immunosuppressive therapy three years after his surgery. Shortly after stopping therapy, he demonstrated clinical manifestations of kidney failure. Which type of reaction does this represent?

A. "This drug has a longer duration of action than some of the other antibiotics."
Explanation: Azithromycin, a macrolide antibiotic, has a longer half-life in the body compared to some other antibiotics. Half-life refers to the time it takes for half of the drug to be eliminated from the body. A longer half-life means the drug remains effective for a longer duration, allowing for less frequent dosing.

B. "This is a much more effective drug than what you received previously."
Explanation: While azithromycin is effective against a wide range of bacterial infections, it's not accurate to say it's universally more effective than other antibiotics. The choice of antibiotic depends on the specific type of infection and the susceptibility of the bacteria causing it. Effectiveness varies based on the context of use.

C. "I'll call the pharmacy and ask about the chemical makeup of the drug."
Explanation: While understanding the chemical makeup of drugs is important for healthcare professionals, it might not directly answer the patient's question about the dosing frequency. Explaining the drug's pharmacological properties, such as its duration of action, would provide a more relevant and understandable response to the patient's query.

D. "You'll need to ask your healthcare provider questions like that."
Explanation: This response does not provide the patient with the information they seek. Nurses are valuable resources for medication-related questions and should strive to provide accurate and understandable explanations to patients.

A. Reddened tongue and gums: This side effect is not typically associated with ampicillin. However, certain medications or medical conditions can cause changes in oral tissues, leading to redness in the tongue and gums.

B. Digit numbness and tingling: Ampicillin does not commonly cause numbness and tingling in the fingers and toes. These symptoms can be associated with neurological issues or circulatory problems.

C. Bruising and petechiae: These symptoms can indicate bleeding disorders or low platelet count and are not usually caused by ampicillin. It's essential to investigate further if a patient experiences unexplained bruising or petechiae.

D. Skin rash and loose stools: Skin rash is a known side effect of penicillin-type antibiotics, including ampicillin. Loose stools or diarrhea can also occur due to disruption of the gut flora caused by the antibiotic. Patients should be aware of these possibilities and report any severe or persistent symptoms to their healthcare provider.