Which of the following is a common manifestation of increased intracranial pressure?

A. Ischemia and neuronal death – Cerebral perfusion pressure (CPP) is the pressure needed to ensure adequate blood flow to the brain. If CPP drops too low, the brain doesn't receive enough oxygen and glucose, leading to ischemia and eventually neuronal death.
B. Improved cognitive function – Low CPP results in decreased oxygen and nutrient delivery, which impairs cognitive and neurological function.
C. Increased blood flow to the brain – Low CPP means reduced blood flow, not increased.
D. Undetectable intracranial glucose levels – While glucose delivery may decrease, levels are not necessarily undetectable and this is not the primary concern with low CPP.

A. Hypertrophy increases oxygen demand but does not improve cardiac function; it typically worsens ejection fraction.
B. Hypertrophy and remodeling initially help compensate but over time lead to inefficient heart muscle with poor contractility and increased oxygen demand, contributing to worsening heart failure.
C. Hypertrophy and remodeling increase, not reduce, workload, and do not resolve heart failure.
D. Contractility often declines and oxygen demand increases, contrary to this statement.