Wound healing that occurs with minimal tissue loss, absence of scarring, and the tissue quickly returns to its normal state describes which type of healing?
Scar formation
Regeneration
Resolution
Replacement
The Correct Answer is B
Rationale:
A. Scar formation occurs when there is significant tissue loss or damage, and the tissue cannot be restored to its original structure. Fibroblasts produce collagen to fill the defect, resulting in a fibrous scar. Healing is complete structurally but the tissue does not regain normal function or appearance, making this different from the healing described in the question.
B. Regeneration refers to the restoration of injured tissue to its normal structure and function with minimal tissue loss and no scarring. Cells that retain the ability to divide, such as epithelial cells or liver cells, replace the damaged cells and restore tissue to its original state. This is the ideal type of healing when the injury is superficial or limited, allowing tissues to fully recover.
C. Resolution is the process by which minimal tissue damage occurs, and the tissue returns to normal without significant repair mechanisms being activated. While similar to regeneration, resolution is typically used to describe inflammation resolution, such as in mild infections, rather than wound healing per se.
D. Replacement occurs when tissue is healed by connective tissue rather than the original cells, leading to scar formation. It is typical when the original tissue cannot regenerate, such as in severe burns or myocardial infarction. Replacement restores structural integrity but not normal function, making it different from regeneration.
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Naxlex Comprehensive Predictor Exams
Related Questions
Correct Answer is B
Explanation
Rationale:
A. Collagen production is associated with tissue repair and chronic inflammation, not the initial acute inflammatory response. Acute inflammation primarily involves cellular and vascular changes, rather than significant collagen deposition.
B. Acute inflammation is characterized by rapid onset, short duration, and prominent vascular changes, including vasodilation and increased capillary permeability. These changes lead to redness, warmth, swelling (edema), pain, and exudate formation as plasma proteins and leukocytes move into the injured tissue. Swelling and exudate are hallmark features that differentiate acute from chronic inflammation.
C. Tissue destruction is more associated with chronic inflammation, where persistent injury and immune activity can lead to fibrosis, granuloma formation, and progressive tissue damage. Acute inflammation may involve minimal tissue injury that is typically reversible.
D. Scar tissue formation occurs mainly in chronic inflammation or the later repair phase after tissue damage. Acute inflammation primarily focuses on eliminating the injurious agent and initiating repair, not extensive fibrosis.
Correct Answer is C
Explanation
Rationale:
A. Atrophy is a decrease in cell size and function due to disuse, reduced blood flow, or aging. It is not associated with malignancy or loss of differentiation.
B. Metaplasia is the reversible replacement of one mature cell type with another in response to chronic stress or irritation. While it can precede malignancy in some cases (e.g., Barrett’s esophagus), metaplasia itself does not show undifferentiated cells or nuclear variability.
C. Anaplasia refers to cells that have lost their differentiation and show pleomorphism—meaning variability in cell size, shape, and nuclear structure. It is a hallmark of malignant tumors, indicating aggressive, uncontrolled growth and poor prognosis. Features include hyperchromatic nuclei, abnormal mitoses, and loss of normal tissue organization.
D. Hypertrophy is an increase in cell size due to increased workload or stress, without loss of differentiation. It is a physiologic or adaptive response, not associated with malignancy.
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