The HESI A2 Biology test covers basic biology topics that include metabolism, molecules, genetics photosynthesis, and DNA. This article will look at the important things you need to know, such as how many questions you must answer, the test design, and the HESI Biology practice test that will help you prepare.

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hesi biology practice test

HESI Biology Practice Test

The HESI Biology practice test is an important resource that helps aspiring nurses prepare for their actual HESI Biology test. The practice test allows the test takers to be familiar with the test format and the question types they will encounter. It also helps them identify the areas they will have to improve. When you use the Naxlex HESI Biology practice test, candidates will be in a better position to understand the type of biology questions they will tackle during their exams. It will also help make them more comfortable with their abilities.

There are different types of HESI biology practice test questions. There are subject-specific and full-length practice tests. The full-length biology practice test questions are more comprehensive and offer a realistic simulation of the actual HESI Biology test. However, all these question types have their benefits and will help you prepare well for the exams . You should set aside a specific study time to ensure proper use of the HESI Biology practice test kit. They should strive to answer as many questions as possible.

When you are through with answering the HESI Biology practice test questions, you can review the answers and point out areas where you might have made mistakes. With this, you can point out places where you should put more emphasis on your studies.  Test takers preparing for their HESI Biology test must take the HESI Biology practice test under similar conditions. They will take the actual exam and use the same time and quiet environment as they will in the Test. Online quizzes and flashcards offer a great way to practice Biology concepts and help improve your knowledge of biology. The online quizzes will allow test takers to practice particular Biology topics in different formats. The flashcards will help ensure the proper practice of other Biology concepts quickly and easily.

How Many Questions Are on HESI Biology Test?

The biology subtest comprises 30 multiple-choice questions. Five questions are always used for evaluation in future tests and never count towards or against the score. It is difficult for exam takers to identify the scored and the non-scored questions. Four possible answers always follow every question. You have to choose the right answer to receive question credits. Every question will always have one correct answer.You will have to answer all the questions within 25 minutes.

You will have approximately 50 seconds to spend on every question. It means you must pay attention to how much time you spend on every question. When a question seems quite complex, consider making the best guess and proceed to the next question. You can always return to your unsure questions and try redoing them.

What is on HESI Biology Exam?

The HESI Biology exam tests your general knowledge of biology. Some of the topics you will encounter include

Biology Basics

They will test your understanding of gradualism, scientific methods, kingdom classification systems, natural selection, and evolution.


Questions about water will ask you to demonstrate your knowledge of different water properties like adhesion, heat, solvency, and cohesion

Biologic Molecules

Some questions will test your understanding of reactions such as catabolic and anabolic, the four basic building blocks, and the four basic macromolecules.


These questions will prompt you to demonstrate your understanding of metabolism.

The Cell

Here, you will be asked to demonstrate your knowledge of the structure and function of cells. Specific understanding of chromosomes, nuclei, nuclear pores, cytoplasm, ribosomes, cell membranes, and related concepts.

Cellular Respiration

The common topics you will be tested on are metabolic reactions within the cell, oxidation, Krebs cycle, glycolysis, respiration, and chemiosmosis. You will also be tested on genetics, DNA, cellular reproduction, and photosynthesis.

Questions on HESI Biology Practice Test

Correct Answer is B


Dermal papillae are small, raised structures in the dermis of the skin. They contain nerve endings, capillaries, and other specialized cells. Dermal papillae are responsible for creating fingerprints, as they push up into the epidermis and create ridges on the surface of the skin. These ridges are what give each person their unique patern of fingerprints. Sudoriferous glands are responsible for producing sweat, Merkel cells are involved in touch sensation, and arrector pili are responsible for the contraction of hair follicles

Correct Answer is C


The ABCD rule is a mnemonic used to identify the characteristics of melanoma, which is a type of skin cancer. The leters stand for:

A -Asymmetry: One half of the mole or lesion does not match the other half.

B - Border irregularity: The edges are ragged, notched, or blurred.

C - Color: The color is not uniform and may include different shades of brown or black, or sometimes patches of pink, red, white, or blue.

D - Diameter: The size of the mole or lesion is greater than 6 mm (about the size of a pencil eraser), although melanomas can sometimes be smaller.

This rule is not as useful in detecting other types of skin cancer, such as squamous cell carcinoma, basal cell carcinoma, or sarcoma, as they tend to have different characteristics. However, any new or changing mole or lesion on the skin should be examined by a dermatologist to determine if it is cancerous.

Correct Answer is A


Lysosomes contribute to phagocytosis in white blood cells by fusing with the phagosome, which is the membrane-bound vesicle that engulfs the foreign particle or pathogen during phagocytosis. The lysosomes contain hydrolytic enzymes that can break down the engulfed material, thereby helping to destroy the invading pathogen. Additionally, lysosomes can also release reactive oxygen species and other antimicrobial molecules that further aid in the destruction of the pathogen.

Vacuoles, endoplasmic reticulum, and Golgi apparatus do not directly contribute to phagocytosis in white blood cells. Vacuoles are used for storage in cells, while the endoplasmic reticulum and Golgi apparatus are involved in protein synthesis and processing.

Correct Answer is B


Hematoma formation occurs immediately after the bone is fractured. The blood vessels that have been damaged due to the fracture bleed and form a hematoma or a blood clot.

Next, callus formation begins, which involves the accumulation of fibrous tissue, cartilage, and new bone cells around the fracture site, forming a soft callus.

The soft callus then undergoes callus ossification, in which the fibrous tissue and cartilage are gradually replaced by hardened new bone tissue.

Finally, bone remodeling occurs, which involves the reshaping of the newly formed bone tissue to match the shape of the original bone, and the removal of any excess bone material.

Therefore, option b, hematoma formation, Callus formation, Callus ossification, Bone remodeling, is the correct sequence of repair as a fractured bone goes through the healing process.

Correct Answer is B


After birth, blood is primarily produced in the red bone marrow of the infant. Red bone marrow is a spongy tissue found in the hollow centers of certain bones, such as the skull, ribs, pelvis, and long bones of the arms and legs. Red bone marrow is responsible for producing red blood cells, white blood cells, and platelets.

In adults, some of the blood production shifts to other organs such as the spleen and liver. However, in infants, the red bone marrow is the main site of blood cell production until about 5 years of age when it begins to gradually transition to the other organs.


Correct Answer is A


The ureters are long, narrow tubes that transport urine from the kidneys to the urinary bladder. Each kidney has one ureter, which emerges from the renal pelvis (a funnel-shaped cavity in the kidney) and descends downward, passing behind the peritoneum and along the back of the abdominal cavity. The ureters then enter the bladder through small openings at the base of the bladder, where they join with the urethra, a tube that carries urine out of the body.

Correct Answer is A


Ceruminous glands are specialized sweat glands located in the skin of the ear canal. These glands secrete a waxy substance called cerumen or ear wax. Ear wax helps to lubricate and protect the skin of the ear canal and prevent the entry of foreign particles, such as dust and insects, into the ear. It also has antibacterial properties that help to protect the ear from infection. The amount and composition of ear wax vary from person to person and can be affected by factors such as age, genetics, and environmental conditions.

Correct Answer is B


The xiphoid process is a small, cartilaginous extension located at the inferior end of the sternum (breastbone), which serves as an attachment site for certain abdominal muscles. The hyoid bone is a U- shaped bone located in the neck, not on the sternum. The ossa coxae are also known as the hip bones, which are in the pelvic region, not on the sternum. Sesamoid bones are small, rounded bones that are embedded within tendons and can be found in various locations throughout the body, but not necessarily on the sternum.

Correct Answer is A


Eating large amounts of turnips and beets can lead to a condition called beeturia, which causes the urine and skin to turn a reddish or purplish color. This condition is harmless and is caused by the betalain pigments present in these vegetables. As a strict vegetarian, it is possible that the client consumes large amounts of these vegetables, which could explain the unusual skin color.

Rice and eggs, carrots and squash, spinach and mustard greens are not known to cause unusual skin color. However, it is important for the nurse to ask the client about her diet and any supplements she may be taking to beter understand the cause of the unusual skin color.

Correct Answer is D


A ball and socket joint is a type of synovial joint where the rounded head of one bone fits into the concave socket of another bone, allowing movement in multiple directions. The shoulder joint is a classic example of a ball and socket joint, where the rounded head of the humerus bone fits into the shallow socket of the scapula bone, allowing for a wide range of movements such as flexion, extension, abduction, adduction, and rotation. The ankle joint is a hinge joint, the elbow joint is a hinge joint, and the knee joint is a complex hinge joint.

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