A client is receiving high doses of methotrexate and is experiencing severe bone marrow suppression. The nurse expects which intervention to be ordered with this drug to reduce this problem?
Therapy with filgrastim
Leucovorin rescue
A transfusion of whole blood
Administration of allopurinol
The Correct Answer is B
B. methotrexate is a dihydrofolate reductase inhibitor which inhibits synthesis of building block for DNA synthesis and repair
A. Filgrastim is a growth factor used to boost neutrophil production
C. Transfusion-maybe necessary in the case of severe anemia
D. Allopurinol is an anti-uricemic agent used in gout
Nursing Test Bank
Naxlex Comprehensive Predictor Exams
Related Questions
Correct Answer is ["B","C","D"]
Explanation
methotrexate interferes with DNA synthesis which may affect all rapidly dividing cells including hair follicles, oral epithelial lining and bone marrow cells involved in fighting against infections
A. Hair loss is expected
B, E. Methotrexate should be taken with a lot of fluid to flush down the drug to minimize nausea and vomiting
Correct Answer is D
Explanation
D. Therapeutic index refers to the doses that results in desired outcome with adverse effects. It is between the safe and toxic levels. Narrow therapeutic level means the two are very close.
A. How effective a drug is termed as efficacy
B. Such a drug does not exist as it is not safe
C. Effectiveness of very small dose is termed as potency
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