A nurse cares for a client who tests positive for alpha-antitrypsin (AAT) deficiency.
The client asks, "What does this mean?" How would the nurse respond?
Your children will be at high risk for chronic obstructive pulmonary disease.
I will contact a genetic counselor to discuss your condition.
Your risk for chronic obstructive pulmonary disease is higher, especially if you smoke.
This is a recessive gene and would have no impact on your health.
The Correct Answer is C
Choice A rationale
Alpha-1 antitrypsin (AAT) deficiency is an autosomal co-dominant genetic disorder, not strictly recessive. While individuals with two deficient alleles (PiZZ) are at highest risk, heterozygous carriers (PiMZ) also have an increased risk for developing COPD, particularly with environmental exposures like smoking. Therefore, stating children will be at high risk is an oversimplification and potentially inaccurate regarding the genetic transmission pattern.
Choice B rationale
While genetic counseling is an appropriate recommendation for individuals with AAT deficiency to understand inheritance patterns and reproductive risks, it is not the most immediate and direct response regarding the client's personal health implications. The client's question focuses on what the diagnosis means for *them*, not their offspring initially.
Choice C rationale
AAT deficiency significantly increases the risk for developing emphysema, a form of COPD, especially when compounded by environmental factors such as smoking. AAT normally protects lung tissue from elastase, and its deficiency leads to unchecked protease activity and subsequent lung destruction. This response directly addresses the client's personal health risk and a major modifiable factor.
Choice D rationale
This statement is inaccurate. AAT deficiency is not a recessive gene in a simple Mendelian sense where only homozygous recessive individuals are affected. It's an autosomal co-dominant condition where both alleles contribute to AAT levels, and even heterozygous carriers (PiMZ) can have lower AAT levels and increased risk for COPD, especially with smoking. Thus, it certainly impacts health.
Nursing Test Bank
Naxlex Comprehensive Predictor Exams
Related Questions
Correct Answer is A
Explanation
Choice A rationale
Tachypnea, or rapid breathing, significantly increases insensible fluid loss through the respiratory tract. Each exhalation carries water vapor, and with increased respiratory rate and depth, the total volume of water lost through respiration can be substantial, leading to dehydration despite oral fluid intake. This explains the physiological mechanism of fluid imbalance related to respiratory effort.
Choice B rationale
While pneumonia can be associated with dehydration due to fever, decreased oral intake, and increased metabolic demands, stating that "everyone with pneumonia is dehydrated" is an overgeneralization and not scientifically accurate. The degree of dehydration varies among individuals based on their specific physiological response and hydration status.
Choice C rationale
While intravenous fluids are often used to administer antibiotics, the client specifically asked about dehydration despite drinking water. This response avoids directly addressing the client's concern and the physiological reason for their dehydration, missing an opportunity for client education regarding their condition.
Choice D rationale
This response is a therapeutic communication technique, but in this specific scenario, the client is directly asking for a scientific explanation of their dehydration. Responding with another question shifts the burden of explanation back to the client and does not provide the requested physiological information, which is critical for their understanding and adherence. .
Correct Answer is A
Explanation
Choice A rationale
Ethambutol, an antitubercular medication, is known to cause optic neuritis as a significant adverse effect. This condition manifests as inflammation of the optic nerve, leading to decreased visual acuity, red-green color discrimination impairment, and even blindness. Therefore, regular monitoring of visual acuity and color vision is crucial throughout the duration of ethambutol therapy.
Choice B rationale
Skin color changes are not a primary adverse effect of ethambutol. While some antitubercular drugs like rifampin can cause orange-red discoloration of bodily fluids, ethambutol's adverse effect profile primarily targets the ocular system. Monitoring skin color would not be an effective or necessary assessment for ethambutol therapy.
Choice C rationale
While overall renal function is important for drug excretion, ethambutol does not typically cause significant changes in urine output. It is primarily excreted renally, and dose adjustments may be needed in renal impairment, but direct monitoring of urine output as a specific adverse effect of ethambutol is not the primary concern.
Choice D rationale
Cardiac rhythm disturbances are not a commonly associated adverse effect of ethambutol. Antitubercular medications like isoniazid can rarely cause cardiac issues, but ethambutol's predominant and significant toxicity is to the optic nerve. Therefore, monitoring cardiac rhythm is not a routine or primary assessment for ethambutol therapy.
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