A nurse is assessing a child with suspected infective endocarditis. Which finding is most indicative of this condition?

Choice A rationale

The setting-sun sign is a clinical finding where the infant's eyes appear to be driven downward, with the sclera visible above the iris, resembling the sun setting below the horizon. This is highly indicative of hydrocephalus as the increased intracranial pressure (ICP) presses on the midbrain tectum, causing paralysis of upward gaze.

Choice B rationale

A high-pitched, shrill cry is a non-specific sign of neurological distress and is often associated with increased intracranial pressure (ICP). While it can occur with hydrocephalus, it is a less specific and less consistent finding than the setting-sun sign, which directly reflects the mechanical pressure effects on the oculomotor and associated midbrain structures.

Choice C rationale

A sunken or depressed fontanel is a classic sign of dehydration or hypovolemia due to decreased intracranial volume. Conversely, an infant with hydrocephalus, characterized by excessive cerebrospinal fluid accumulation, will typically present with a bulging, tense, and non-pulsatile anterior fontanel due to the severely elevated intracranial pressure.

Choice D rationale

Normal head circumference would be an unexpected finding in an infant with significant, uncompensated hydrocephalus. The defining clinical feature in infants is the rapid and often exaggerated increase in head circumference (macrocephaly), as the cranial sutures are not yet fused, allowing the head to expand markedly to accommodate the accumulating cerebrospinal fluid and rising pressure.

Choice A rationale

Periorbital edema (swelling around the eyes) is a common sign of nephrotic syndrome or other systemic fluid overload states, such as congestive heart failure. While heart failure can be a complication of severe infective endocarditis (IE), periorbital edema is a non-specific finding and not a primary, classic physical finding of the infection itself.

Choice B rationale

Bounding pulses in the lower extremities are most characteristic of a condition causing a wide pulse pressure, such as a large patent ductus arteriosus (PDA) or aortic regurgitation. While aortic valve damage can occur in IE, the bounding pulse is not a hallmark finding directly resulting from the infectious process.

Choice C rationale

A high-pitched cry is a non-specific sign of neurological distress or pain in an infant. While systemic infection and potential septic emboli from infective endocarditis could affect the central nervous system, this symptom is not a primary or expected clinical manifestation of the localized heart valve infection.

Choice D rationale

Splinter hemorrhages are small, linear, dark-red streaks that appear under the nails. They are a classic peripheral sign of infective endocarditis caused by microemboli (tiny fragments of the infected vegetation) lodging in the distal capillaries of the nail bed, making this a highly indicative finding.