A nurse is caring for a client who is on warfarin therapy for atrial fibrillation. The client's INR is 5.2. Which of the following medications should the nurse prepare to administer?

Choice A reason: Infection is the correct condition that the client is at increased risk for. Agranulocytosis is a severe decrease in the number of granulocytes, which are a type of white blood cell that fight infection. Propylthiouracil is an antithyroid drug that can cause agranulocytosis as a rare but serious side effect. The client with agranulocytosis is more susceptible to bacterial and fungal infections, and may present with fever, sore throat, mouth ulcers, and skin lesions.

Choice B reason: Excessive bleeding is not the correct condition that the client is at increased risk for. Agranulocytosis does not affect the platelets, which are the blood cells that help with clotting. Propylthiouracil does not cause bleeding disorders, although it may interact with anticoagulants and increase their effect.

Choice C reason: Hyperglycemia is not the correct condition that the client is at increased risk for. Agranulocytosis does not affect the insulin, which is the hormone that regulates blood glucose levels. Propylthiouracil does not cause hyperglycemia, although it may interfere with the metabolism of oral hypoglycemic agents and decrease their effect.

Choice D reason: Ecchymosis is not the correct condition that the client is at increased risk for. Ecchymosis is a bruise caused by bleeding under the skin. Agranulocytosis does not cause ecchymosis, as it does not affect the blood vessels or the platelets. Propylthiouracil does not cause ecchymosis, although it may increase the risk of skin rash and pruritus.

Choice A reason: Blood pressure 160/94 mm Hg is not a reason to withhold atenolol, as it is a beta-blocker that lowers blood pressure and reduces the workload of the heart. Atenolol is indicated for hypertension, angina, and arrhythmias. The nurse should administer atenolol as prescribed, unless the blood pressure is too low (hypotension).

Choice B reason: Heart rate 46/min is a reason to withhold atenolol, as it is a sign of bradycardia (slow heart rate), which can be a side effect of atenolol. Atenolol can decrease the heart rate by blocking the beta-1 receptors in the heart. The nurse should withhold atenolol if the heart rate is below 60 beats per minute or above 100 beats per minute, and report the finding to the provider.

Choice C reason: Oxygen saturation 95% is not a reason to withhold atenolol, as it is a normal value that indicates adequate oxygenation of the blood. Atenolol does not affect the oxygen saturation or the respiratory function. The nurse should monitor the oxygen saturation regularly, and report any signs of hypoxia (low oxygen level).

Choice D reason: Respiratory rate 18/min is not a reason to withhold atenolol, as it is a normal value that indicates normal breathing. Atenolol does not affect the respiratory rate or the respiratory function. The nurse should monitor the respiratory rate regularly, and report any signs of dyspnea (difficulty breathing).