A nurse is consulting a pharmacological reference about medication compatibility prior to administering warfarin to a client.
Which of the following medications should the nurse identify as being incompatible with warfarin?

Naproxen.

Magnesium hydroxide.

Lisinopril.

Propranolol.

Answer and Explanation

The Correct Answer is A

Choice A rationale:

Naproxen is a nonsteroidal anti-inflammatory drug (NSAID) and can increase the risk of bleeding when used with warfarin, which is an anticoagulant medication. Combining these two medications can lead to excessive bleeding and is considered incompatible.

Choice B rationale:

Magnesium hydroxide is an antacid and does not have significant interactions with warfarin. It does not affect the anticoagulant properties of warfarin.

Choice C rationale:

Lisinopril is an angiotensin-converting enzyme (ACE) inhibitor used to treat high blood pressure and heart failure. It does not have a significant interaction with warfarin.

Choice D rationale:

Propranolol is a beta-blocker used to treat high blood pressure, angina, and other heart conditions. It does not have a significant interaction with warfarin.

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Correct Answer is A

Explanation

A. Heart rate 58/min. B. Fasting blood glucose 100 mg/dL. C. WBC count 2,900/mm3. D. Hgb 14 g/dL.

Correct Answer is C

Explanation

Choice A rationale:

Heart rate 58/min. Clozapine, an atypical antipsychotic medication, can cause bradycardia (slow heart rate) as a side effect. However, the heart rate of 58/min is within the normal range for adults, so it is not a contraindication for clozapine administration.

Choice B rationale:

Fasting blood glucose 100 mg/dL. A fasting blood glucose level of 100 mg/dL is within the normal range (70-99 mg/dL) for adults. It is not a contraindication for clozapine administration.

Choice C rationale:

WBC count 2,900/mm3. Clozapine can cause agranulocytosis, a severe reduction in white blood cell (WBC) count, which can lead to increased susceptibility to infections. A WBC count of 2,900/mm3 is significantly below the normal range (4,000-11,000/mm3) and is a contraindication for clozapine administration due to the risk of severe immunosuppression.

Choice D rationale:

Hgb 14 g/dL. Hemoglobin (Hgb) level of 14 g/dL is within the normal range for adult males (13.8-17.2 g/dL) and females (12.1-15.1 g/dL). It is not a contraindication for clozapine administration.

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A nurse is consulting a pharmacological reference about medication compatibility prior to administering warfarin to a client.
Which of the following medications should the nurse identify as being incompatible with warfarin?