A nurse is obtaining a medication history from a client who has hypertension. Which of the following questions should the nurse ask to assess for adherence to the prescribed therapy?

B) Correct. The nurse should ask about any over-the-counter medications or supplements that the client is taking, as they may interact with the prescribed antihypertensive medications or affect blood pressure control.

A) Incorrect. This question is relevant for monitoring blood pressure, but not for assessing adherence to the prescribed therapy.

C) Incorrect. This question is relevant for evaluating the client's knowledge of their medications, but not for assessing adherence to the prescribed therapy.

D) Incorrect. This question is relevant for ensuring proper medication safety, but not for assessing adherence to the prescribed therapy.

A) Correct. The nurse should instruct the client to take metformin with meals to reduce gastrointestinal upset, such as nausea, vomiting, diarrhea, or abdominal pain, which are common adverse effects of this medication.

B) Incorrect. The nurse should not instruct the client to take metformin at bedtime, as this may increase the risk of lactic acidosis, a rare but serious complication of this medication that can cause muscle pain, weakness, fatigue, or hyperventilation.

C) Incorrect. The nurse should not instruct the client to take metformin with grapefruit juice, as this may interfere with its metabolism and increase its blood levels, which can lead to hypoglycemia or low blood sugar levels.

D) Incorrect. The nurse should not instruct the client to take metformin with an antacid, as this may decrease its absorption and effectiveness in lowering blood sugar levels.